Quantitative proviral DNA and antibody levels in the natural history of HTLV-I infection
| Autor: | Angela Manns, William A. Blattner, Owen St. C. Morgan, Seth L. Welles, David Waters, Elizabeth M. Maloney, Rainford J. Wilks, Barrie Hanchard, Beverly Cranston, Wendell J. Miley, Gilian Wharfe |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Adolescent Virus Proviruses immune system diseases Pregnancy hemic and lymphatic diseases Tropical spastic paraparesis medicine Immunology and Allergy Humans Leukemia-Lymphoma Adult T-Cell Blood Transfusion Prospective Studies Seroconversion Pregnancy Complications Infectious Aged Human T-lymphotropic virus 1 biology Antibody titer virus diseases Middle Aged Viral Load medicine.disease biology.organism_classification Virology HTLV-I Infections Paraparesis Tropical Spastic HTLV-I Antibodies Infectious Diseases Immunology Carrier State DNA Viral biology.protein Disease Progression Female Antibody Asymptomatic carrier Viral load |
| Zdroj: | The Journal of infectious diseases. 180(5) |
| ISSN: | 0022-1899 |
| Popis: | The pathogenesis of human T-cell lymphotropic virus type I (HTLV-I) in adult T-cell leukemia/lymphoma (ATL) and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is poorly understood. We prospectively followed up and evaluated the virologic correlates of infection in transfusion recipients after seroconversion, in asymptomatic carriers, and in ATL and HAM/TSP patients. Proviral DNA levels (copies/105 lymphocytes) were determined by real-time automated polymerase chain reaction and antibody titers by end-point dilution by use of an HTLV-I enzyme-linked immunoassay. In early infection, proviral load was initially elevated (median, 212 copies/105 lymphocytes at time 1) and later decreased (median, 99 copies at time 2, and 27 copies at time 3). Corresponding antibody titers were low at time 1 (1:2154), had significantly increased by time 2 (1:12312), and were stable by time 3 (1:4694). These viral markers were significantly lower in asymptomatic carriers than in HAM/TSP or ATL patients. Therefore, proviral load and antibody titers may be useful as predictive markers of disease among carriers. |
| Databáze: | OpenAIRE |
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