Pharmacokinetic Study of Compound K in Japanese Subjects After Ingestion of Panax ginseng Fermented by Lactobacillus paracasei A221 Reveals Significant Increase of Absorption into Blood
| Autor: | Nobuya Matsuoka, Taro Ueda, Hiroyuki Fukami |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Lactobacillus paracasei Ginsenosides Metabolite Saponin Medicine (miscellaneous) Panax complex mixtures 03 medical and health sciences chemistry.chemical_compound Ginseng 0302 clinical medicine Pharmacokinetics Japan Ingestion Humans Testosterone Food science chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Cross-Over Studies biology food and beverages Glycoside Lacticaseibacillus paracasei Middle Aged biology.organism_classification chemistry Ginsenoside 030220 oncology & carcinogenesis Fermentation Female |
| Zdroj: | Journal of medicinal food. 22(3) |
| ISSN: | 1557-7600 |
| Popis: | Compound K (CK) is a metabolite of a saponin in Panax ginseng, formed from ginsenoside, a triterpenoid glycoside, by human intestinal bacteria. Lactobacillus paracasei A221 isolated from fermented food can hydrolyze (deglycosylate) the main ginsenoside, ginsenoside Rb1, and generate CK. However, the pharmacokinetics of L. paracasei A221 fermented ginseng (FG) and nonfermented ginseng (NFG) have not been investigated so far. The aim of this study was to investigate the pharmacokinetics of CK after oral administration of single doses of FG and NFG in healthy Japanese adults. An open-label, randomized, single-dose, two-period, crossover study was conducted in 12 Japanese healthy volunteers (five men and seven women, aged 40-60 years). All subjects were equally allocated into two groups and administered tablets containing FG or NFG. Until 24 h after the administration, blood samples were sequentially collected, plasma concentrations of CK were measured, and the pharmacokinetic parameters were calculated. We also expected restoration of decreased testosterone level as one of the beneficial effects of FG and measured plasma total testosterone concentrations in male volunteers. The means of T |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|