Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity
| Autor: | Tetsu Goto, Shiro Yorifuji, Kuriko Kagitani-Shimono, Hiroyuki Uchida, Masayuki Hirata, Masako Taniike, Tomoka Yamamoto, Wakako Sanefuji, Ikuko Mohri, Junko Matsuzaki, Saeko Sakai |
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| Rok vydání: | 2012 |
| Předmět: |
Auditory Cortex
Male medicine.medical_specialty medicine.diagnostic_test Autistic spectrum disorder business.industry General Neuroscience Magnetoencephalography Audiology Auditory cortex Hyperacusis Acoustic Stimulation Child Development Disorders Pervasive Characteristic response Evoked Potentials Auditory Auditory stimuli medicine Humans Child Auditory Physiology business Cognitive psychology |
| Zdroj: | NeuroReport. 23:113-118 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/wnr.0b013e32834ebf44 |
| Popis: | The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were larger than those in the other two groups [corrected]. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it. |
| Databáze: | OpenAIRE |
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