Distribution of Serum Adiponectin Isoforms in Pediatric Patients with Steroid-Sensitive Nephrotic Syndrome
| Autor: | Atsutoshi Shiratori, Satoshi Hibino, Kazushige Dobashi, Yoshifusa Abe, Yoshitaka Watanabe, Shuichiro Watanabe, Satomi Nimura, Tsuneki Watanabe, Yuya Nakano, Katsumi Mizuno, Yasuko Nakano, Kaori Kamijo, Kazuo Itabashi, Tetsuro Tamai, Hirokazu Ikeda, Shunsuke Sakurai, Takaaki Takayanagi |
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| Rok vydání: | 2020 |
| Předmět: |
Nephrology
Gene isoform Male medicine.medical_specialty Nephrotic Syndrome Physiology Steroid-sensitive nephrotic syndrome Prednisolone Anti-Inflammatory Agents 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine medicine Distribution (pharmacology) Humans Protein Isoforms High-molecular-weight Child Serum adiponectin Children Proteinuria Adiponectin business.industry Remission Induction Adiponectin isoform Infant food and beverages medicine.disease Molecular Weight Endocrinology Case-Control Studies Child Preschool Original Article Female medicine.symptom business Nephrotic syndrome |
| Zdroj: | Clinical and Experimental Nephrology |
| Popis: | Background Serum adiponectin circulates in three multimeric isoforms: high-molecular-weight (HMW), middle-molecular-weight (MMW), and low-molecular-weight (LMW) isoforms. Potential change in the circulating adiponectin levels in patients with nephrotic syndrome (NS) remain unknown. This study aimed to assess the levels of total adiponectin and the distribution of its isoforms in pediatric patients with NS. Methods We sequentially measured total adiponectin and each adiponectin isoform levels at the onset of NS, initial remission, and during the remission period of the disease in 31 NS patients. We also calculated the ratios of HMW (%HMW), MMW (%MMW), and LMW (%LMW) to total adiponectin incuding 51 control subjects. Results The median of total serum adiponectin levels in patients were 36.7, 36.7, and 20.2 μg/mL at the onset, at initial remission, and during the remission period of NS, respectively. These values were significantly higher than those in control subjects. The median values of %HMW, %MMW, and %LMW values were 56.9/27.0/14.1 at the onset, 62.0/21.8/13.4 at the initial remission, and 58.1/21.7/17.5 at during the remission period of NS, respectively. Compared with control subjects, %HMW at initial remission and %MMW at the onset were high, and the %LMW values at the onset and at initial remission were low. Conclusions In patients with NS, total serum adiponectin levels increase at the onset of the disease, and the ratio of adiponectin isoforms changes during the course of the disease. Further studies are needed to delineate the mechanisms between proteinuria and adiponectin isoforms change. |
| Databáze: | OpenAIRE |
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