The Current Epidemiology of Injecting Drug Use-Associated Infective Endocarditis in Victoria, Australia in the Midst of Increasing Crystal Methamphetamine Use
| Autor: | Ohide Otome, Eugene Athan, Alexandra Wright, Craig Harvey, Steven J. Bowe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Adolescent Victoria Population 030204 cardiovascular system & hematology Rate ratio Risk Assessment Methamphetamine 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Epidemiology medicine Humans 030212 general & internal medicine Risk factor education Substance Abuse Intravenous Aged education.field_of_study business.industry Incidence (epidemiology) Incidence Endocarditis Bacterial Middle Aged medicine.disease Confidence interval Surgery Infective endocarditis Cohort Central Nervous System Stimulants Female Cardiology and Cardiovascular Medicine business Demography |
| Zdroj: | Heart, lungcirculation. 27(4) |
| ISSN: | 1444-2892 |
| Popis: | Background Infective endocarditis (IE) is associated with significant mortality and morbidity despite recent advances in management. Injecting drug use (IDU) remains an important risk factor. Our aim was to evaluate the rates and patient demographics of IE and injecting drug use-associated infective endocarditis (IDU-IE) in Victoria from 2009 to 2014. Methods The Victorian Admitted Episode Dataset (VAED) was used to identify a population-based cohort with a diagnosis of IE and IDU-IE between 2009 and 2014 in Victoria. Incidence rates were calculated per 100,000 people/year. Rate ratios were calculated using Poisson distributions, and chi squared (χ 2 ) test for trend were calculated to identify significant linear trends. Results The incidence rate of IE overall has risen significantly from 11.09 to 13.56 per 100,000 people/year from 2009 to 2014 (rate ratio 1.22, 95% confidence interval (CI) 1.10, 1.36, p 2 ) test for trend of both IE and IDU-IE also suggests a statistically significant linear trend (p=0.0015 and 0.005 respectively). Descriptive epidemiology revealed men are twice as likely to be affected by IE overall. The elderly were found to be the most affected by IE overall (ages 75 to 79 years) with IDU-IE affecting a much younger age group (ages 30 to 34 years). Validation of hospital coding for IDU-IE was shown to have sensitivity of 77.2% (95% CI 64.8, 86.2). Conclusions This study identified that from 2009 to 2014 there has been a significant increase in incidence of both IE overall and IDU-IE in Victoria. These findings highlight the need for the planning of targeted interventions to mitigate the incidence of disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect