Dataset of GWAS-identified variants underlying venous thromboembolism susceptibility and linkage to cancer aggressiveness
| Autor: | Joana Assis, Rui Medeiros, Valéria Tavares, Ricardo Pinto, Deolinda Pereira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Candidate gene
Cancer hallmarks Single-nucleotide polymorphism Genome-wide association study Disease Computational biology lcsh:Computer applications to medicine. Medical informatics 03 medical and health sciences 0302 clinical medicine Biochemistry Genetics and Molecular Biology GWAS Medicine cardiovascular diseases Validation reports lcsh:Science (General) 030304 developmental biology Genetic association 0303 health sciences Multidisciplinary business.industry Cancer medicine.disease Review article The Hallmarks of Cancer lcsh:R858-859.7 business 030217 neurology & neurosurgery lcsh:Q1-390 Venous thromboembolism SNPs |
| Zdroj: | Data in Brief Data in Brief, Vol 30, Iss, Pp 105399-(2020) |
| ISSN: | 2352-3409 |
| DOI: | 10.1016/j.dib.2020.105399 |
| Popis: | Venous thromboembolism (VTE) is a common cardiovascular disease, for which several single nucleotide polymorphisms (SNPs) underlying susceptibility were identified. Apart from candidate gene approach, genome-wide association studies (GWAS) have contributed to the identification of novel VTE-associated SNPs, including some with no clear role in the haemostatic system. These genetic variants constitute potential cancer-related biomarkers, particularly predictive and prognostic biomarkers, as a two-way association between VTE and cancer is well established. The present dataset comprises the data obtained from GWAS performed to identify genetic variants associated with VTE risk. Furthermore, this dataset also comprises data regarding previously reported candidate gene and validation reports performed in adults of European ancestry that also analysed the VTE GWAS-identified variants. Lastly, to evaluate the impact of these genetic variants in carcinogenesis, a broad search was made, which has let us to establish putative links between several VTE-associated genes and cancer hallmarks in a review article entitled “Venous thromboembolism GWAS reported genetic makeup and the hallmarks of cancer: linkage to ovarian tumour behaviour”. |
| Databáze: | OpenAIRE |
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