A case of convergent evolution: Several viral and bacterial pathogens hijack RSK kinases through a common linear motif
| Autor: | Frédéric Sorgeloos, Michael Peeters, Yohei Hayashi, Fabian Borghese, Nicolas Capelli, Melissa Drappier, Teresa Cesaro, Didier Colau, Vincent Stroobant, Didier Vertommen, Grégory de Bodt, Stéphane Messe, Ignasi Forné, Felix Mueller-Planitz, Jean-François Collet, Thomas Michiels |
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| Přispěvatelé: | Université Catholique de Louvain = Catholic University of Louvain (UCL), Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier]-Université de Montpellier (UM), Ludwig Institute for Cancer Research, Ludwig-Maximilians-Universität München (LMU), DIAMANT-BERGER, Valérie |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Gene Expression Regulation
Viral Mitogen-Activated Protein Kinase Kinases type-3 secretion Multidisciplinary Bacteria Host Microbial Interactions MAP Kinase Signaling System viruses Bacterial Infections Virus Replication Biological Evolution Ribosomal Protein S6 Kinases 90-kDa [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity short linear motif Cell Line Immediate-Early Proteins picornavirus Virus Diseases [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Viruses [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Humans host–pathogen interaction innate immunity [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2022, 119 (5), pp.e2114647119. ⟨10.1073/pnas.2114647119⟩ |
| ISSN: | 0027-8424 1091-6490 |
| DOI: | 10.1073/pnas.2114647119⟩ |
| Popis: | International audience; Microbes have been coevolving with their host for millions of years, exploiting host resources to their own benefit. We show that viral and bacterial pathogens convergently evolved to hijack cellular mitogen-activated protein kinase (MAPK) p90-ribosomal S6-kinases (RSKs). Theiler’s virus leader (L) protein binds RSKs and prevents their dephosphorylation, thus maintaining the kinases active. Recruitment of RSKs enables L-protein-mediated inhibition of eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2 or PKR) and stress granule formation. Strikingly, ORF45 protein of Kaposi’s sarcoma-associated herpesvirus (KSHV) and YopM protein of Yersinia use the same peptide motif as L to recruit and activate RSKs. All three proteins interact with a conserved surface-located loop of RSKs, likely acting as an allosteric regulation site. Some unrelated viruses and bacteria thus evolved to harness RSKs in a common fashion, yet to target distinct aspects of innate immunity. As documented for Varicella zoster virus ORF11, additional pathogens likely evolved to hijack RSKs, using a similar short linear motif |
| Databáze: | OpenAIRE |
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