Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis
| Autor: | Giovanni Pacini, Giovanni Musso, Monica Carello, Marilena Durazzo, Maurizio Cassader, Gianfranco Pagano, Franco De Michieli, Giampaolo Biroli, Emanuela Fagà, Mario Rizzetto, Roberto Gambino |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Liver Cirrhosis Male Nonalcoholic steatohepatitis medicine.medical_specialty Necrosis macromolecular substances Gastroenterology Medical Records Body Mass Index Insulin-Secreting Cells Internal medicine Glucose Intolerance medicine Homeostasis Humans Glucose tolerance test Hepatology medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Case-control study Feeding Behavior Glucose Tolerance Test Adaptation Physiological Fatty Liver Glucose medicine.anatomical_structure Endocrinology Case-Control Studies Female Adiponectin Insulin Resistance medicine.symptom Hepatic fibrosis Pancreas business Body mass index Forecasting |
| Zdroj: | The American journal of gastroenterology 100 (2005): 2438–2446. doi:10.1111/j.1572-0241.2005.00297.x info:cnr-pdr/source/autori:Musso G., Gambino R., Biroli G., Carello M., Fagà E., Pacini G., De Michieli F., Cassader M., Durazzo M., Rizzetto M., and Pagano G./titolo:Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis/doi:10.1111%2Fj.1572-0241.2005.00297.x/rivista:The American journal of gastroenterology/anno:2005/pagina_da:2438/pagina_a:2446/intervallo_pagine:2438–2446/volume:100 |
| DOI: | 10.1111/j.1572-0241.2005.00297.x |
| Popis: | OBJECTIVES: The relationships between the adipokines tumor necrosis factor (TNF)-? and adiponectin and the parameters of glucose homeostasis and severity of liver disease were assessed in nonobese nondiabetic subjects with nonalcoholic steatohepatitis (NASH). METHODS: A frequently sampled intravenous glucose tolerance test, serum cytokine measurement, and 7-day alimentary record were performed in 20 biopsy-proven NASH patients and 45 age-, sex-, and BMI-matched controls (30 insulin sensitive and 15 insulin resistant). RESULTS: Patients with NASH had impaired pancreatic ?-cell function compared with both insulin-sensitive (adaptation index, AI: 97.7 ± 17.7 vs 307.4 ± 24.1 min -2 mmol -1 L; p = 0.00001) and insulin-resistant (adaptation index, AI: 97.7 ± 17.7 vs 201.4 ± 41.1 min -2 mmol -1 L; p = 0.001) controls. Serum adiponectin levels were also significantly lower in the NASH group than in the two control groups and correlated with adaptation index and with the severity of hepatic steatosis, necroinflammation, and fibrosis. When NASH patients were grouped according to the severity of histological liver damage, adiponectin was the only variable discriminating patients with higher necroinflammatory grade and fibrosis score from those with milder lesions. CONCLUSIONS: ?-cell secretory impairment is present in nonobese patients with NASH before glucose intolerance appears and may contribute to their increased risk for developing diabetes. Hypoadiponectinemia is a feature of NASH and may have a pathogenetic role in ?-cell dysfunction and in hepatic necroinflammation and fibrosis, independently of insulin resistance, visceral fat accumulation, TNF-? axis activity, and dietary habits. Our findings provide further rationale for therapeutic approaches aimed at increasing adiponectin levels together with restoring ?-cell function and insulin sensitivity. |
| Databáze: | OpenAIRE |
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