The use of quantitative scintigraphy in the measurement of portal-systemic shunting in rats
| Autor: | David H. Van Thiel, W. Newlon Tauxe, Teruhito Mochizuki, Rudolf E. Stauber |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Collateral Circulation Portal vein ligation Scintigraphy law.invention Ileocolic vein Rats Sprague-Dawley law Hypertension Portal medicine Animals Radiology Nuclear Medicine and imaging Radionuclide Imaging Technetium Tc 99m Aggregated Albumin Gamma camera Lung medicine.diagnostic_test business.industry General Medicine medicine.disease Chromium Radioisotopes Microspheres Rats Shunting Portal System medicine.anatomical_structure Portal systemic shunting Portal hypertension Regression Analysis Radiology Nuclear medicine business Liver Circulation |
| Zdroj: | Annals of nuclear medicine. 6(4) |
| ISSN: | 0914-7187 |
| Popis: | Portal-systemic shunting was studied in 54 portal hypertensive rats both in vivo and in vitro using radioactive microspheres. The animals underwent partial portal vein ligation around needles of varying diameter to produce a wide range of shunting. Two to four weeks later, quantitative lung-liver scintigraphic and whole body images were obtained in vivo following ileocolic vein injection with 99mTc-MAA. After sacrifice, the lung and liver activities were determined by the gamma camera, a dose calibrator, and a well counter. Portal-systemic shunting ranged from 0.1-97.6%. When shunting was compared in vivo and in vitro, an excellent correlation was found (r = 0.99, p0.001). A subgroup of 24 animals had consecutive injections of 99mTc-MAA and 51Cr-labeled 15 microns microspheres, which, although different in size, yielded similar results (r = 0.89, p0.001). We conclude that in small laboratory animals a wide range of shunting can be measured accurately in vivo by quantitative scintigraphy. |
| Databáze: | OpenAIRE |
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