Accelerated corneal crosslinking in children with keratoconus: 5-year results and comparison of 2 protocols
| Autor: | Mehmet Emin Sucu, Alper Agca, B. Tülü, Korhan Fazil, Selim Genç, Yusuf Yildirim, Dilek Yaşa, Burcin Kepez Yildiz |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Keratoconus Adolescent genetic structures Ultraviolet Rays Corneal Stroma Riboflavin Visual Acuity Refraction Ocular Application time law.invention law Ophthalmology medicine Humans Manifest refraction Child Dioptre Retrospective Studies Coma Photosensitizing Agents Keratometer business.industry Corneal Topography medicine.disease eye diseases Sensory Systems Cross-Linking Reagents Treatment Outcome Photochemotherapy Case-Control Studies Female Surgery Collagen sense organs medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of Cataract and Refractive Surgery. 46:517-523 |
| ISSN: | 1873-4502 0886-3350 |
| DOI: | 10.1097/j.jcrs.0000000000000101 |
| Popis: | Purpose To evaluate long-term clinical results of 2 different accelerated corneal crosslinking (CXL) protocols in pediatric patients with keratoconus. Setting Beyoglu Eye Training and Research Hospital, Istanbul, Turkey. Design Retrospective case-control study. Methods Patients who were younger than 18 years were included in the study. Group 1 received 4 minutes of illumination at 30 mW/cm, and Group 2 received 5 minutes of illumination at 18 mW/cm. Uncorrected and corrected distance visual acuities, manifest refraction, corneal topographic parameters, and corneal higher-order aberrations (HOAs) were evaluated at baseline and during 1-, 3-, and 5-year follow-up visits. Results A total of 143 eyes from 86 patients were included in the study. There were 30 eyes in Group 1 and 113 eyes in Group 2. The mean follow-up time was 4.15 ± 0.99 years. Mean keratometry (K) and/or maximum K progressed ≥1.00 diopter (D) in 7 eyes (23.3%) in Group 1 and 19 eyes (16.8%) in Group 2 (P = .411). Mean K and/or maximum K decreased ≥2.00 D in 2 eyes (6.7%) in Group 1 and 24 eyes (21.2%) in Group 2 (P = .06). In Group 1, there were no statistically significant differences in topographic parameters during follow-up. In Group 2, there was a statistically significant reduction in total HOA and coma during the 5-year visit when compared with the preoperative visit (P = .005 and P = .045, respectively). Conclusions Accelerated CXL is beneficial in terms of halting the progression of keratoconus in pediatric patients throughout 5 years of follow-up examinations. An increased irradiance with a reduced application time reduces the topographic effects of CXL. |
| Databáze: | OpenAIRE |
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