Interaction between single nucleotide polymorphism in catalase: Gene and catalase activity under the conditions of oxidative stress
| Autor: | S. N. Gyrylova, Korostileva Ka, T. G. Ruksha, A. V. Komina, R N Belonogov |
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| Předmět: |
Adult
Male Antioxidant Genotype Physiology medicine.medical_treatment Single-nucleotide polymorphism medicine.disease_cause Peripheral blood mononuclear cell Polymorphism Single Nucleotide Young Adult medicine Humans Alleles chemistry.chemical_classification Reactive oxygen species biology Promoter General Medicine Middle Aged Catalase Molecular biology Oxidative Stress Enzyme chemistry Mutation biology.protein Leukocytes Mononuclear Female Reactive Oxygen Species Oxidative stress |
| Zdroj: | Scopus-Elsevier |
| Popis: | Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The –262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H2O2-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H2O2. Genotype-dependent response of catalase activity to oxidative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress. |
| Databáze: | OpenAIRE |
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