Oxidative stress and the etiology of insulin resistance and type 2 diabetes
| Autor: | Elizabeth M. Marchionne, Maggie K. Diamond-Stanic, Erik J. Henriksen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment medicine.disease_cause p38 Mitogen-Activated Protein Kinases Biochemistry Article Antioxidants Insulin resistance Superoxides Physiology (medical) Internal medicine medicine Animals Humans Prediabetes Muscle Skeletal chemistry.chemical_classification Reactive oxygen species NADPH oxidase biology Insulin NADPH Oxidases Skeletal muscle Hydrogen Peroxide medicine.disease Disease Models Animal Oxidative Stress Insulin receptor Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry biology.protein Insulin Resistance Energy Metabolism Reactive Oxygen Species Oxidative stress Signal Transduction |
| Zdroj: | Free Radical Biology and Medicine. 51:993-999 |
| ISSN: | 0891-5849 |
| DOI: | 10.1016/j.freeradbiomed.2010.12.005 |
| Popis: | The condition of oxidative stress arises when oxidant production exceeds antioxidant activity in cells and plasma. The overabundance of oxidants is mechanistically connected with the multifactorial etiology of insulin resistance, primarily in skeletal muscle tissue, and the subsequent development of type 2 diabetes. Two important mechanisms for this oxidant excess are 1) the mitochondrial overproduction of hydrogen peroxide and superoxide ion in conditions of energy surplus and 2) the enhanced activation of cellular NADPH oxidase via angiotensin II (AT1) receptors. Several recent studies are reviewed that support the concept that direct exposure of mammalian skeletal muscle to an oxidant stress (including hydrogen peroxide) results in stimulation of the serine kinase p38 mitogen-activated protein kinase (p38 MAPK), and that the engagement of this stress-activated p38 MAPK signaling is mechanistically associated with diminished insulin-dependent stimulation of insulin signaling elements and glucose transport activity. The beneficial interactions between the antioxidant α-lipoic acid and the advanced glycation end product inhibitor pyridoxamine to ameliorate oxidant stress-associated defects in whole-body and skeletal muscle insulin action in the obese Zucker rat, a model of pre-diabetes, are also addressed. Overall, this review highlights the importance of oxidative stress in the development of insulin resistance in mammalian skeletal muscle tissue, at least in part via a p38 MAPK-dependent mechanism, and indicates that interventions that reduce this oxidative stress and oxidative damage can improve insulin action in insulin-resistant animal models. Strategies to prevent and ameliorate oxidative stress remain important in the overall treatment of insulin resistance and type 2 diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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