Effect of pharmacist intervention on improving antidepressant medication adherence and depression symptomology: A systematic review and meta-analysis
| Autor: | J. Scott Parrott, Kevin C. Readdean, Albert J. Heuer |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Psychological intervention Pharmaceutical Science Pharmacy Cochrane Library Pharmacists Medication Adherence 03 medical and health sciences 0302 clinical medicine Professional Role Intervention (counseling) medicine Humans 030212 general & internal medicine Pharmacist intervention Depression (differential diagnoses) business.industry Depression Odds ratio Antidepressive Agents 030227 psychiatry Meta-analysis Physical therapy Antidepressant Controlled Clinical Trials as Topic business |
| Zdroj: | Research in socialadministrative pharmacy : RSAP. 14(4) |
| ISSN: | 1934-8150 |
| Popis: | Background Depression is a widespread disease with effective pharmacological treatments, but low medication adherence. Pharmacists play a key role in supporting medication adherence in patients with depression given their accessibility to patients. Purpose The aim of this review was to systematically evaluate the impact of pharmacist interventions on adherence to antidepressants and clinical symptomology among adult outpatients with depressive disorders. Methods A systematic review of controlled trials (both randomized and non-randomized) was conducted. Studies were obtained through a search of PubMed, Academic Search Premier, and Cochrane Library databases. Studies which included a pharmacist intervention to improve medication adherence in outpatients age 17 and above with a depressive disorder diagnosis and antidepressant treatment were included. Twelve publications met inclusion criteria, representing a total of 15,087 subjects: 1379 (9%) intervention and 13,708 (91%) control. Results The interventions in each selected publication included some level of in-person counseling and education to promote antidepressant adherence. The pooled odds ratio for medication adherence at 6 months was 2.50 (95% CI 1.62 to 3.86). There were no significant differences noted in subgroup meta-analyses except study location (US, Middle East or Europe) and setting. Only one of the identified studies reported statistically significant impacts of the pharmacist intervention on patient depression symptoms. Conclusions The findings suggest that pharmacist interventions can enhance patient adherence to antidepressant medication in adult outpatients. However, this review failed to demonstrate a positive effect of these interventions on clinical symptoms. Additional longitudinal research is recommended to investigate the multidimensional relationships between pharmacist interventions, patient adherence, and clinical outcomes. Article synopsis Pharmacists play a key role in supporting medication adherence in patients with depression given their accessibility to patients. The purpose of this review was to systematically evaluate the impact of pharmacist interventions on adherence to antidepressants and clinical symptomology among adult outpatients with depressive disorders. A systematic review of randomized and non-randomized controlled trials was conducted of the twelve studies which met inclusion criteria. The findings suggest that pharmacist interventions can enhance patient adherence to antidepressant medication in adult outpatients. However, this review failed to demonstrate a positive effect of these interventions on clinical symptoms. |
| Databáze: | OpenAIRE |
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