Histochemical investigation of malignant cells
| Autor: | Guy Heyden |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Histology Cell Glucosephosphate Dehydrogenase Biology medicine.disease_cause Epithelium Cell Line Mice medicine Carcinoma Atypia Animals Molecular Biology Vulvar Neoplasms Histocytochemistry Epithelial Cells Keratosis Neoplasms Experimental Cell Biology General Medicine medicine.disease Rats Medical Laboratory Technology medicine.anatomical_structure Carcinoma Basal Cell Dysplasia Cell culture Carcinoma Squamous Cell Experimental pathology Female Mouth Neoplasms Anatomy General Agricultural and Biological Sciences Carcinogenesis Carcinoma in Situ HeLa Cells Methylcholanthrene |
| Zdroj: | Histochemistry. 39:327-334 |
| ISSN: | 1432-119X 0301-5564 |
| Popis: | By means of a modified histochemical method for demonstrating glucose-6-phosphate dehydrogenase activity in an atmosphere saturated with oxygen it proved possible to record malignant cells in tissue sections and cell cultures. Tests were performed on potentially malignant and established malignant human epithelial lesions, on different stages of experimental squamous cell carcinomas in the rat and on cell cultures of malignant cells. Clinically healthy epithelium, benign lesions and cell cultures of benign cells served as controls. The occurrence of strongly positive cytoplasmic enzyme reactions in malignant cells may be termed metabolic atypia. In experimental carcinogenesis this form of atypia seemed to procede visible morphologic atypia (dysplasia). Further studies are in progress to evaluate the utilization of the histochemical recordings, in addition to ordinary histologic analyses, in routine differential diagnostic work. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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