Keratins 7 and 20 as diagnostic markers of carcinomas metastatic to the ovary
| Autor: | Frank Smedts, Fred T. Bosman, Louis G.M Gerrits, Frans C. S. Ramaekers, Carla C.A.P. Wauters |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Mesothelioma
Pathology medicine.medical_specialty endocrine system diseases Ovary Keratin-20 Biology Adenocarcinoma Pathology and Forensic Medicine Metastasis Cytokeratin Intermediate Filament Proteins Ovarian carcinoma Keratin medicine Biomarkers Tumor Humans chemistry.chemical_classification Ovarian Neoplasms integumentary system Keratin 20 Antibodies Monoclonal medicine.disease medicine.anatomical_structure chemistry Keratin 7 Keratin 8 Keratins Female |
| Zdroj: | Human pathology. 26(8) |
| ISSN: | 0046-8177 |
| Popis: | The most common carcinomas metastatic to the ovary that mimic ovarian primaries are colonic adenocarcinomas and endometrial carcinomas. Conventional histochemical staining procedures, even in combination with additional immunohistochemical assays, are of limited value in distinguishing between these metastases and primary ovarian carcinomas. In this study we investigated whether the application of monoclonal antibodies against keratins 7, 8, and 20 could help in differentiating between these categories. The reactivity patterns of 40 carcinomas metastatic to the ovary were compared with those of their primary carcinomas on the one hand and with various primary ovarian carcinomas and mesotheliomas on the other. Colon cancer metastatic to the ovary was keratin 7 negative and keratin 20 positive in 94% of the cases; in contrast, all primary ovarian carcinomas were keratin 7 positive and keratin 20 negative, with the exception of two cases of mucinous cystadenocarcinoma. Ovarian metastases of gastric cancer usually contained keratins 7 and 20. Metastases of endometrial cancer to the ovary and primary ovarian carcinomas usually showed similar keratin expression. We propose that keratin 7 and 20 antibodies may be of help to distinguish between primary ovarian carcinomas and carcinoma metastases in the ovary. |
| Databáze: | OpenAIRE |
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