Adding Multiple Adipokines into the Model do not Improve Weight Gain Prediction by Leptin Levels in Newborns
| Autor: | Leonardo Mancillas-Adame, Jesús Zacarías Villarreal-Pérez, Consuelo Treviño-Garza, Manuel Enrique De la O Cavazos, Isaías Rodríguez-Balderrama, Laura Villarreal-Martínez, Cynthia M. Estrada-Zúñiga, Fernando Montes-Tapia |
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| Rok vydání: | 2016 |
| Předmět: |
Leptin
medicine.medical_specialty Endocrinology Diabetes and Metabolism Birth weight Adipokine Adipose tissue 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Adipokines Predictive Value of Tests newborn Internal medicine Plasminogen Activator Inhibitor 1 Birth Weight Humans Medicine Resistin 030212 general & internal medicine Chemokine CCL2 Immunoassay Adiponectin Interleukin-6 Tumor Necrosis Factor-alpha business.industry Infant Newborn Infant weight gain prediction Fetal Blood Adipose Tissue chemistry Plasminogen activator inhibitor-1 Multivariate Analysis Pediatrics Perinatology and Child Health Original Article medicine.symptom business Weight gain hormones hormone substitutes and hormone antagonists Follow-Up Studies |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5727 |
| Popis: | Objective: Most adipose tissue programming is realized in early life. Also, the postnatal three months, rather than the later phases of infancy, may be more relevant in the development of an adverse cardiometabolic risk profile. The adipokines phenotype, as a predictor of early-life weight gain, has been recently explored in cord blood. To determine whether in addition to leptin levels in cord samples, adiponectin, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 (PAI-1), and tumor necrosis factor alpha (TNF-α) levels improve weight gain prediction during the first three months of life. Methods: Adiponectin, IL-6, MCP-1, leptin, resistin, PAI-1, and TNF-α were measured by multiplex immunoassay in a subsample of 86 healthy term newborns. Results: Leptin levels significantly predicted weight gain at 3 months of follow-up (r2=0.09, p=0.006). In the multivariate analysis, including additional adipokines in the model, stepwise or all at once, did not increase the prediction of weight gain after the first three months of life. Conclusion: Adding adiponectin, IL-6, MCP-1, resistin, PAI-1, and TNF-α to the prediction model of weight gain in healthy newborns did not prove to be useful. It is probable that their relative contribution to weight gain is not important. Only leptin was relevant as a predictor of weight gain at the 3-month endpoint. |
| Databáze: | OpenAIRE |
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