Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior
| Autor: | Andrea C. Gore, Michael P. Reilly, Krittika Krishnan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Adolescent Endocrine Disruptors Biology Nervous System Article 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology Animals Humans Endocrine system Nervous System Physiological Phenomena Vinclozolin Child Social Behavior Endocrine and Autonomic Systems Reproduction Phthalate Neurosecretory Systems 030227 psychiatry Adult life chemistry Hypothalamus Hormone receptor Hormone synthesis Environmental Pollutants Neuroscience 030217 neurology & neurosurgery Hormone |
| Zdroj: | Horm Behav |
| ISSN: | 0018-506X |
| Popis: | A contribution to SBN/ICN special issue. Endocrine-disrupting chemicals (EDCs) are pervasive in the environment. They are found in plastics and plasticizers (bisphenol A (BPA) and phthalates), in industrial chemicals such as polychlorinated biphenyls (PCBs), and include some pesticides and fungicides such as vinclozolin. These chemicals act on hormone receptors and their downstream signaling pathways, and can interfere with hormone synthesis, metabolism, and actions. Because the developing brain is particularly sensitive to endogenous hormones, disruptions by EDCs can change neural circuits that form during periods of brain organization. Here, we review the evidence that EDCs affect developing hypothalamic neuroendocrine systems, and change behavioral outcomes in juvenile, adolescent, and adult life in exposed individuals, and even in their descendants. Our focus is on social, communicative and sociosexual behaviors, as how an individual behaves with a same- or opposite-sex conspecific determines that individual's ability to exist in a community, be selected as a mate, and reproduce successfully. |
| Databáze: | OpenAIRE |
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