Measurement of Thyroid Stimulating Hormone(TSH) in Human Urine
| Autor: | Takashi Nomura, Katsumi Yoshida, Kazuro Kaise, Nobuko Kaise, Yoichi Itagaki, Toshiro Sakurada, Shintaro Saito, Makiko Yamamoto, Kaoru Yoshinaga |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Urinary system Thyrotropin Renal function Urine Excretion Endocrinology Hypothyroidism Thyroid-stimulating hormone Internal medicine Humans Medicine Immunoradiometric assay business.industry General Engineering Primary hypothyroidism medicine.disease Proteinuria Glycoprotein Hormones alpha Subunit Female Kidney Diseases beta 2-Microglobulin business Nephrotic syndrome hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrinologia Japonica. 35:733-739 |
| ISSN: | 2185-6370 0013-7219 |
| Popis: | Using a highly sensitive and specific immunoradiometric assay kit for human TSH, we measured TSH concentrations in unprocessed urines in normal subjects, in patients with primary hypothyroidism, and patients with renal disease. In five of ten normal subjects TSH was detectable in urine samples (less than 20-69 microU/day). In five patients with hypothyroidism, the urinary TSH excretion was increased. In seven out of ten patients with nephrotic syndrome, eight out of nine patients with chronic renal failure and two patients with tubular dysfunction, the urinary TSH excretion was increased. The urinary TSH excretion correlated significantly with both urinary protein excretion and urinary beta 2-microglobulin excretion. These results suggest that the renal handling of TSH involves both glomerular filtration and tubular re-absorption, and that urinary TSH excretion is increased when serum TSH is increased and either glomerular or tubular function is impaired. |
| Databáze: | OpenAIRE |
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