HLA-G and anti-HCV in patients on the waiting list for kidney transplantation
| Autor: | Carmela Iannone, Nicolò Rupealta, Linda Sommese, Vincenzo Grimaldi, Antonella Esposito, Rossella Paolillo, Antonio Sorriento, Francesco Cacciatore, Paride De Rosa, Chiara Sabia, Claudio Napoli, Michele Santangelo, Gianfranco Nicoletti, Gerardo Sarno |
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| Přispěvatelé: | Sommese, Linda, Paolillo, Rossella, Cacciatore, Francesco, Grimaldi, Vincenzo, Sabia, Chiara, Esposito, Antonella, Sorriento, Antonio, Iannone, Carmela, Rupealta, Nicolò, Sarno, Gerardo, Santangelo, Michele, De Rosa, Paride, Nicoletti, Gianfranco, Napoli, Claudio, Sommese, L., Paolillo, R., Cacciatore, F., Grimaldi, V., Sabia, C., Esposito, A., Sorriento, A., Iannone, C., Rupealta, N., Sarno, G., Santangelo, M., De Rosa, P., Nicoletti, G., Napoli, C. |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Waiting Lists Hepatitis C virus Hepacivirus HLA-G Human leukocyte antigen Antibodies Viral medicine.disease_cause Major histocompatibility complex Gastroenterology 03 medical and health sciences HLA-G Antigen 0302 clinical medicine Internal medicine medicine Humans Age Factor Kidney transplantation Aged HLA-G Antigens Kidney Hepaciviru biology Tumor Necrosis Factor-alpha business.industry Medicine (all) Age Factors General Medicine Middle Aged biology.organism_classification medicine.disease Kidney Transplantation Interleukin-10 Transplantation 030104 developmental biology medicine.anatomical_structure Solubility HCV biology.protein Female business Human 030215 immunology |
| Zdroj: | Advances in Medical Sciences. 63:317-322 |
| ISSN: | 1896-1126 |
| Popis: | Purpose Human leukocyte antigen (HLA)-G is a non-classic major histocompatibility complex HLA class I molecule. HLA-G may have tolerogenic properties which are linked to epigenetic-sensitive pathways. There is a correlation of sHLA-G levels and graft acceptance in transplantation studies. There are previous data on correlation of sHLA-G with graft rejection as well as with viral infections such as hepatitis C virus (HCV) in kidney transplanted patients. Here, we report the sHLA-G expression in patients on the waiting list for kidney transplantation, with and without anti-HCV compared to a control group. Methods Serum of 67 patients on the waiting list for kidney transplantation (n = 43 with anti-HCV and n = 24 without anti-HCV) was analyzed. Among these patients, n = 39 were on the waiting list for the first transplantation, while n = 28 were patients who returned in the list. The control group included n = 23 blood donors with anti-HCV (n = 13) and without anti-HCV (n = 10). Results The expression of sHLA-G was significantly lower in the control group (39.6 ± 34.1 U/ml) compared to both - patients on the waiting list for the first transplantation (62.5 ± 42.4 U/ml, p=0.031) and patients who returned in the list (76.7 ± 53.9 U/ml, p=0.006). No significant differences were observed in all anti-HCV positive groups. A positive linear correlation between sHLA-G and TNF-α, and patient age was observed. Conclusions Serum sHLA-G values were significantly increased in both - patients on the waiting list for the first transplantation and patients who returned in the list, as compared to control group. Our findings confirm the key tolerogenic role of sHLA-G levels as epigenetic-related marker for measuring the state of kidney allograft acceptance. |
| Databáze: | OpenAIRE |
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