An essential role of Bmp4 in the atrioventricular septation of the mouse heart
| Autor: | Brigid L.M. Hogan, H. Scott Baldwin, Yingna Zhou, Holger Kulessa, Lorene Batts, Kai Jiao, Kevin Tompkins |
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| Rok vydání: | 2003 |
| Předmět: |
Heart Defects
Congenital Heart malformation Mice Transgenic Bone Morphogenetic Protein 4 Bone morphogenetic protein Research Communications Mice Transforming Growth Factor beta2 Endocardial cushion formation Transforming Growth Factor beta Genetic model Genetics medicine Animals Myocytes Cardiac cardiovascular diseases Atrioventricular canal defect Endocardium biology Gene Expression Regulation Developmental Heart Anatomy Transforming growth factor beta medicine.disease Mice Mutant Strains Cell biology Animals Newborn Bone morphogenetic protein 4 Bone Morphogenetic Proteins cardiovascular system biology.protein Signal Transduction Developmental Biology |
| Zdroj: | Genes & Development. 17:2362-2367 |
| ISSN: | 1549-5477 0890-9369 |
| DOI: | 10.1101/gad.1124803 |
| Popis: | Proper septation and valvulogenesis during cardiogenesis depend on interactions between the myocardium and the endocardium. By combining use of a hypomorphic Bone morphogenetic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal from the myocardium directly mediating atrioventricular septation. Defects in this process cause one of the most common human congenital heart abnormalities, atrioventricular canal defect (AVCD). The spectrum of defects obtained through altering Bmp4 expression in the myocardium recapitulates the range of AVCDs diagnosed in patients, thus providing a useful genetic model with AVCD as the primary defect. |
| Databáze: | OpenAIRE |
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