Release of ibuprofen from beads for embolization: in vitro and in vivo studies
| Autor: | P. Prognon, G. Guiffant, A. Kasselouri, J.P. Pelage, T. Borovac, Alexandre Laurent |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_treatment
Chemistry Pharmaceutical Drug Compounding Pharmaceutical Science Ibuprofen Pharmacology Polyvinyl alcohol Excipients chemistry.chemical_compound Pharmacokinetics Uterine artery embolization In vivo medicine Animals Sheep biology Leiomyoma Chemistry Anti-Inflammatory Agents Non-Steroidal Uterus Embolization Therapeutic In vitro Microspheres Solutions Kinetics Solubility Enzyme inhibitor Evaluation Studies as Topic Delayed-Action Preparations Polyvinyl Alcohol biology.protein Liberation Female Powders medicine.drug |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 115(3) |
| ISSN: | 0168-3659 |
| Popis: | Ibuprofen (IBU) loaded polyvinyl alcohol-based hydrogel beads (IBU-BB) were designed to alleviate side effects such as inflammation and pain following uterine artery embolization for the treatment of leiomyomata. The present in vitro and in vivo study examines whether IBU-BB provide a sustained-release of the drug. In vitro release studies of IBU from IBU-BB (10, 50, 100 mg/mL), IBU solution (PEDEA) and IBU powder were compared using the T apparatus and the beaker method. The pharmacokinetic profile of IBU release was examined in vivo, following sheep uterine artery embolization with 100 mg/mL IBU-BB or after intra-arterial injection of IBU solution. IBU-BB can deliver high concentrations of the drug over time. The in vitro release from IBU-BB was markedly slower compared to IBU solution. Increasing the concentration of loaded IBU from 10 to 100 mg/mL decreased the rate of release. IBU release from the T apparatus was slower than the release in the beaker. In vivo, the release of the drug was progressive, without the early peak observed with IBU solution. A high level of correlation was obtained between in vivo and in vitro (T apparatus) results. Theoretically, IBU-BB could sustainably release high concentrations of IBU at the site of the uterine fibroids, which makes it a promising approach for the control of post-embolization pain. |
| Databáze: | OpenAIRE |
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