Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy
| Autor: | Humphrey Hodgson, Camilla Buckley, K. Kumar Changani, Simon D. Taylor-Robinson, Jimmy D. Bell |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Liver Cirrhosis Male In vivo magnetic resonance spectroscopy medicine.medical_specialty Glutamine Glutamic Acid Neuropsychological Tests Biology Creatine Choline Phosphates chemistry.chemical_compound Cortex (anatomy) Internal medicine medicine Humans Hepatic encephalopathy Aged Hepatology Brain Phosphorus Isotopes Electroencephalography Middle Aged medicine.disease Magnetic Resonance Imaging Endocrinology medicine.anatomical_structure chemistry Cerebral cortex Creatinine Hepatic Encephalopathy Female Protons Phosphomonoesters |
| Zdroj: | Liver International. 19:389-398 |
| ISSN: | 1478-3231 1478-3223 |
| DOI: | 10.1111/j.1478-3231.1999.tb00067.x |
| Popis: | Background/Aims: In vivo magnetic resonance spectroscopy can be used to study cerebral metabolism non-invasively. We aimed to correlate 1H and 31P magnetic resonance spectral abnormalities in the brains of patients with subclinical hepatic encephalopathy. Methods: Eighteen patients were studied at 1.5T, with combined 1H and 31P magnetic resonance spectra obtained from multiple voxels in the cerebral cortex and basal ganglia. Peak area ratios of choline, glutamine/glutamate, relative to creatine in the 1H spectra and percentage phosphomonoesters, phosphodiesters and ?NTP signals relative to total 31P signals in the 31P spectra were measured. Results: Six patients did not complete the full examination –31P results are available from 12 patients only. Relative to creatine, there were reductions in choline and elevations in glutamine/glutamate, varying across the brain with choline significantly reduced in occipital cortex (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|