Evaluation of morbidity and mortality after resection for hilar cholangiocarcinoma--a single center experience
| Autor: | Thomas M. van Gulik, Hugo Obertop, Michael F. Gerhards, Dirk J. Gouma, Laurens Th de Wit |
|---|---|
| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Single Center Resection Cholangiocarcinoma Risk Factors medicine Hepatectomy Humans Risk factor Serum Albumin Aged Retrospective Studies Porta hepatis Univariate analysis business.industry Mortality rate Retrospective cohort study Middle Aged Surgery medicine.anatomical_structure Bile Ducts Intrahepatic Bile Duct Neoplasms Female Morbidity business Follow-Up Studies |
| Zdroj: | Surgery, 127(4), 395-404. Mosby Inc. |
| ISSN: | 0039-6060 |
| DOI: | 10.1067/msy.2000.104250 |
| Popis: | Background: Hilar resection, especially in combination with liver resection, results in substantial morbidity and mortality, which clearly influences the overall outcome. In the present study, patients who underwent resection of a proximal bile duct tumor were analyzed with the aim of identifying risk factors for morbidity and mortality. Methods: Between 1983 and 1998, 112 consecutive patients underwent a local resection, which in 32 patients was combined with a hemihepatectomy (11 extended resections). Eighty-four percent of the patients underwent preoperative (endoscopic) drainage. For evaluation of different treatment strategies during the study, the period was divided in three 5-year intervals. Results: Postoperative complications occurred in 65% of the patients. The overall hospital mortality was 15% for local resections and 25% for hemihepatectomies. There was a significantly lower morbidity and no mortality after hilar resection during the last 5 years. A higher Bismuth classification showed significant correlation with postoperative morbidity. Extended liver resections and vascular resections and a preoperative albumin level below 35 g/L were found to be significant predictors of increased mortality in univariate analysis. Conclusions: The overall morbidity and mortality rate in this series is higher than most recently published series. More (extended) liver resections resulted in an increased rate of microscopic tumor-free resections, at the cost of higher hospital morbidity and mortality. Improved preoperative work-ups will result in a selection of patients who might benefit from these extensive resections. Surgery 2000;127:395-404. |
| Databáze: | OpenAIRE |
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