Use of near-infrared spectroscopy and multipoint measurements for quality control of pharmaceutical drug products
| Autor: | Fabien Chauchard, Mathieu Boiret |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Quality Control
Pharmaceutical drug Computer science Process analytical technology media_common.quotation_subject medicine.medical_treatment Analytical chemistry Conveyor belt 02 engineering and technology 01 natural sciences Biochemistry Analytical Chemistry medicine Technology Pharmaceutical Quality (business) Process engineering media_common Active ingredient Spectroscopy Near-Infrared business.industry 010401 analytical chemistry Analytical technique Near-infrared spectroscopy 021001 nanoscience & nanotechnology 0104 chemical sciences Pharmaceutical Preparations Drug product 0210 nano-technology business |
| Zdroj: | Analytical and Bioanalytical Chemistry. 409:683-691 |
| ISSN: | 1618-2650 1618-2642 |
| DOI: | 10.1007/s00216-016-9756-9 |
| Popis: | Near-infrared (NIR) spectroscopy is a non-destructive analytical technique that enables better-understanding and optimization of pharmaceutical processes and final drug products. The use in line is often limited by acquisition speed and sampling area. This work focuses on performing a multipoint measurement at high acquisition speed at the end of the manufacturing process on a conveyor belt system to control both the distribution and the content of active pharmaceutical ingredient within final drug products, i.e., tablets. A specially designed probe with several collection fibers was developed for this study. By measuring spectral and spatial information, it provides physical and chemical knowledge on the final drug product. The NIR probe was installed on a conveyor belt system that enables the analysis of a lot of tablets. The use of these NIR multipoint measurement probes on a conveyor belt system provided an innovative method that has the potential to be used as a new paradigm to ensure the drug product quality at the end of the manufacturing process and as a new analytical method for the real-time release control strategy. Graphical abstract Use of near-infrared spectroscopy and multipoint measurements for quality control of pharmaceutical drug products. |
| Databáze: | OpenAIRE |
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