Neutrophil-lymphocyte Ratio is a Novel Reliable Predictor of Nephropathy, Retinopathy, and Coronary Artery Disease in Indians with Type-2 Diabetes
| Autor: | Sagar Khandare, Zahran Qureshi, Deep Dutta, Vineet Surana, Sachin Chittawar, TN Dubey |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
microvascular complications
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Diabetic nephropathy type-2 diabetes lcsh:Diseases of the endocrine glands. Clinical endocrinology Nephropathy Coronary artery disease 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus medicine 030212 general & internal medicine lcsh:RC799-869 neutrophil-lymphocyte ratio lcsh:RC648-665 business.industry Diabetic retinopathy medicine.disease microvascular inflammation diabetic neuropathy diabetic retinopathy Cardiology Albuminuria lcsh:Diseases of the digestive system. Gastroenterology Original Article medicine.symptom business Retinopathy |
| Zdroj: | Indian Journal of Endocrinology and Metabolism Indian Journal of Endocrinology and Metabolism, Vol 21, Iss 6, Pp 864-870 (2017) |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | Background and Aims: Neutrophil-lymphocyte ratio (NLR) has been suggested to be a predictor of coronary artery disease (CAD), and end-organ damage in type-2 diabetes mellitus (T2DM). Similar data are lacking from Indians with T2DM. Hence, this study aimed to evaluate the role of NLR as a predictor of microvascular complications and CAD in T2DM. Subjects and Methods: Consecutive T2DM patients attending the outpatient services of 2 different hospitals, who gave consent, underwent clinical, anthropometric evaluation, and evaluation for the occurrence of retinopathy, nephropathy, neuropathy, and CAD. Results: A total of 298 patients were screened of which 265 patients' data were analyzed. Occurrence of hypertension, neuropathy, nephropathy, retinopathy, and CAD was 12.8%, 18.5%, 41.5%, 62.3%, and 3.8%, respectively. Patients in higher NLR quartiles had significantly higher diabetes duration, occurrence of nephropathy, albuminuria, retinopathy, CAD and lpwer glomerular filtration rate. Patients with more microvascular complications had significantly longer diabetes duration, blood pressure, NLR, creatinine, and urine albumin excretion. Binary logistic regression revealed NLR followed by body mass index were best predictors of microvascular complications. NLR had areas under the receiver operating characteristic curve (AUC) of 0.888 (95% CI: 0.848–0.929; P < 0.001), 0.708 (95% CI: 0.646–0.771; P < 0.001), and 0.768 (95% CI: 0.599–938; P = 0.004) in predicting albuminuria, retinopathy, and CAD, respectively. NLR of 2.00 had sensitivity and specificity of 86.4% and 69% in predicting albuminuria; sensitivity and specificity of 64.2% and 63% in predicting retinopathy; sensitivity and specificity of 80% and 47.1% in predicting CAD. Conclusion: NLR is inexpensive, easy to use, reliable predictor of nephropathy, retinopathy, and CAD in Indian T2DM. |
| Databáze: | OpenAIRE |
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