Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5 '-triphosphate-binding cassette transporter 1 expression
| Autor: | Julia M. Huber, Mats Rudling, Andreas Ritsch, Frans Stellaard, Egon Demetz, Wilfried Schgoer, Kristina Duwensee, Ivan Tancevski, Kathrin Hochegger, Catherine Fievet, Andreas Wehinger, Philipp Eller, Josef R. Patsch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Biology DISEASE chemistry.chemical_compound Endocrinology High-density lipoprotein HDL-CHOLESTEROL Internal medicine medicine ABSORPTION ABCA1 TRANSPORTER Secretion Scavenger receptor IN-VIVO TRANSGENIC MICE Cholesterol Transporter SR-BI Adenosine Sterol ATP Binding Cassette Transporter 1 chemistry RECEPTOR CLASS-B lipids (amino acids peptides and proteins) OVEREXPRESSION medicine.drug LIPIDS |
| Zdroj: | Endocrinology, 149(7), 3708-3712. ENDOCRINE SOC |
| ISSN: | 0013-7227 |
| DOI: | 10.1210/en.2007-1387 |
| Popis: | The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T3 up-regulate hepatic expression of scavenger receptor class B, type I, resulting in increased clearance of plasma HDL-C. Here, we show that severe hyperthyroidism in mice did not affect hepatic expression of scavenger receptor class B, type I, but reduced hepatic expression of ATP-binding cassette transporter 1, accompanied by a 40% reduction of HDL-C. The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7α-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [3H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1. |
| Databáze: | OpenAIRE |
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