Effect of live and inactivated Lactobacillus rhamnosus GG on experimentally induced rhinovirus colds: randomised, double blind, placebo-controlled pilot trial
| Autor: | Riitta Korpela, Minna Kumpu, Birgit Winther, E. K. Allen, J. O. Hendley, Anne Pitkäranta, Soile Tynkkynen, Riina A. Kekkonen, Salme Järvenpää, Hannu Kautiainen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Rhinovirus Common Cold medicine.disease_cause Placebo Microbiology Virus law.invention Placebos 03 medical and health sciences Probiotic Lactobacillus rhamnosus Double-Blind Method law medicine Immunologic Factors 030304 developmental biology 0303 health sciences biology 030306 microbiology business.industry Lacticaseibacillus rhamnosus Probiotics Common cold medicine.disease biology.organism_classification 3. Good health Diarrhea Treatment Outcome Immunology Nasal administration medicine.symptom business |
| Zdroj: | Beneficial microbes. 6(5) |
| ISSN: | 1876-2891 |
| Popis: | The aim of this work was to investigate the usability of an experimental rhinovirus model in probiotic trials aiming to assess effectiveness in viral infections, and to provide preliminary data of live and inactivated probiotic Lactobacillus rhamnosus GG for larger-scale trials utilising the model. 59 subjects were randomised to receive 100 ml of fruit juice supplemented with 109 cfu of live or heat-inactivated (by spray-drying) L. rhamnosus GG or control juice daily for six weeks. After three weeks subjects were intranasally inoculated with experimental rhinovirus. Infection rate (at least one positive culture for challenge virus on five days following inoculation or at least four-fold rise in antibody response to challenge virus) was 14/19 in the group receiving live probiotic strain and 18/20 both in the group receiving heat-inactivated probiotic strain and in the control group (P=0.36). The occurrence and severity of cold symptoms on the five days following the inoculation was lowest in the group receiving live probiotic strain (P=0.45). This trial was the first one dedicated to the investigation of the effect of probiotics using the experimental rhinovirus model. The model showed potential for demonstration of efficacy of probiotics in controlled respiratory viral infections. Occurrence and severity of cold symptoms and number of subjects with rhinovirus infection was lowest in the group receiving live L. rhamnosus GG, but differences were not statistically significant. Further large-scale studies are needed to demonstrate the efficacy of L. rhamnosus GG in respiratory infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|