Lipase‐Powered Mesoporous Silica Nanomotors for Triglyceride Degradation
| Autor: | Lei Wang, Ana C. Hortelão, Xin Huang, Samuel Sánchez |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Tributyrin
Diffusion Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis chemistry.chemical_compound Nanotechnology Triglicèrids Lipase Triglycerides Triacetin Candida biology Triglyceride Nanotecnologia 010405 organic chemistry Substrate (chemistry) General Medicine General Chemistry Mesoporous silica Enzymes Immobilized Silicon Dioxide 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Chemical engineering biology.protein Nanoparticles 0210 nano-technology |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201900697 |
| Popis: | © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We report lipase-based nanomotors that are capable of enhanced Brownian motion over long periods of time in triglyceride solution and of degrading triglyceride droplets that mimic “blood lipids”. We achieved about 40 min of enhanced diffusion of lipase-modified mesoporous silica nanoparticles (MSNPs) through a biocatalytic reaction between lipase and its corresponding water-soluble oil substrate (triacetin) as fuel, which resulted in an enhanced diffusion coefficient (ca. 50 % increase) at low triacetin concentration ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text