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Context: Children with obesity are at higher risk of cardiovascular disease, type 2 diabetes mellitus and premature death compared to their adult counterparts. Objective: We aimed to evaluate the circulating lipidome of pediatric patients compared to adults, including changes after a metabolic intervention, to decipher whether lipid species modulated by bariatric surgery were associated with childhood obesity. Design: Prospective study. Six-months follow-up. Setting: Referral single center. Patients and Interventions: Ten pediatric and thirty adult patients with obesity that, respectively, received lifestyle recommendations (PE cohort) or underwent bariatric surgery (AD cohort), were recruited. Main outcome Measure(s): Clinical parameters and lipidome were analyzed in serum before and after six months of metabolic intervention. Results: The abundance of phosphatidylinositols in PE cohort and phosphatidylcolines in AD significantly increased, while that of O- phosphatidylserines in PE cohort and diacyl/triacylglycerols in AD decreased. Only fifteen lipid species were coincident in both groups. In PE, O-phosphatidylserine levels positively correlated with BMI, weight and insulinemia, and inversely with creatinine, triglycerides, total protein, and urea. In AD, diacyl/triacylglycerols showed a positive correlation with insulinemia, triglycerides, total protein, and urea, whereas a negative correlation was observed between phosphatidylcholines and transaminases and cholesterol. Conclusions: Bariatric surgery and lifestyle intervention produced significant changes in serum lipidome, and only some in both PE and AD cohorts, which therefore may be regarded as biomarkers involved in early obesity and metabolic alterations. |
