Comparative Pharmacokinetics and Pharmacodynamics of a Novel Sodium-Glucose Cotransporter 2 Inhibitor, DWP16001, with Dapagliflozin and Ipragliflozin
| Autor: | Im-Sook Song, Mi Jie Park, So Jeong Nam, Ji-Soo Choi, Min-Koo Choi, Hye-Young Ji |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pharmaceutical Science
lcsh:RS1-441 030209 endocrinology & metabolism Pharmacology 030226 pharmacology & pharmacy Article lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics medicine Distribution (pharmacology) Dapagliflozin IC50 kidney distribution Kidney inhibition mode urogenital system sodium-glucose cotransporter 2 (SGLT2) inhibitors Renal glucose reabsorption Ipragliflozin medicine.anatomical_structure chemistry DWP16001 SGLT2 Inhibitor |
| Zdroj: | Pharmaceutics Volume 12 Issue 3 Pharmaceutics, Vol 12, Iss 3, p 268 (2020) |
| ISSN: | 1999-4923 |
| DOI: | 10.3390/pharmaceutics12030268 |
| Popis: | Since sodium-glucose cotransporter 2 (SGLT2) inhibitors reduced blood glucose level by inhibiting renal tubular glucose reabsorption mediated by SGLT2, we aimed to investigate the pharmacokinetics and kidney distribution of DWP16001, a novel SGLT2 inhibitor, and to compare these properties with those of dapagliflozin and ipragliflozin, representative SGLT2 inhibitors. The plasma exposure of DWP16001 was comparable with that of ipragliflozin but higher than that of dapagliflozin. DWP16001 showed the highest kidney distribution among three SGLT2 inhibitors when expressed as an area under curve (AUC) ratio of kidney to plasma (85.0 ± 16.1 for DWP16001, 64.6 ± 31.8 for dapagliflozin and 38.4 ± 5.3 for ipragliflozin). The organic anion transporter-mediated kidney uptake of DWP16001 could be partly attributed to the highest kidney uptake. Additionally, DWP16001 had the lowest half-maximal inhibitory concentration (IC50) to SGLT2, a target transporter (0.8 ± 0.3 nM for DWP16001, 1.6 ± 0.3 nM for dapagliflozin, and 8.9 ± 1.7 nM for ipragliflozin). The inhibition mode of DWP16001 on SGLT2 was reversible and competitive, but the recovery of the SGLT2 inhibition after the removal of SGLT2 inhibitors in CHO cells overexpressing SGLT2 was retained with DWP16001, which is not the case with dapagliflozin and ipragliflozin. In conclusion, selective and competitive SGLT2 inhibition of DWP16001 could potentiate the efficacy of DWP16001 in coordination with the higher kidney distribution and retained SGLT2 inhibition of DWP16001 relative to dapagliflozin and ipragliflozin. |
| Databáze: | OpenAIRE |
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