2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist
| Autor: | M. A. Savage, Awilda Stapelfeld, Timothy J. Hagen, E. Ann Hallinan, Sofya Tsymbalov |
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| Rok vydání: | 2001 |
| Předmět: |
Chemistry
Stereochemistry Organic Chemistry Clinical Biochemistry Antagonist Pharmaceutical Science Hydrazide Biochemistry Chemical synthesis In vitro Dinoprostone Receptor subtype chemistry.chemical_compound Oxazepines Thiazoles Hydrazines Drug Discovery Molecular Medicine Moiety Pharmacophore Molecular Biology Prostaglandin G2 Oxazoles |
| Zdroj: | Bioorganicmedicinal chemistry. 9(1) |
| ISSN: | 0968-0896 |
| Popis: | 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride ( 1 , SC-51089) is a functional PGE 2 antagonist selective for the EP 1 receptor subtype with antinociceptive activity. 1,2 Analogues of SC-51089, in which the diacylhydrazine moiety has been replaced with 2,4-disubstituted-oxazoles and-thiazoles, are described. |
| Databáze: | OpenAIRE |
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