QUALITATIVE STUDIES OF NEUTRAL 17-KETOSTEROIDS IN NORMAL SUBJECTS*†
| Autor: | Robert B. Wilkins, Loren D. Carlson |
|---|---|
| Rok vydání: | 1952 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Biochemistry Excretion chemistry.chemical_compound Endocrinology Internal medicine polycyclic compounds medicine Androsterone Etiocholanolone Adrenal cortex Biochemistry (medical) medicine.disease 17-Ketosteroids Body Fluids medicine.anatomical_structure chemistry Addison's disease Steroids Cortisone hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 12:647-665 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-12-6-647 |
| Popis: | TOTAL urinary neutral 17-ketosteroids have been studied extensively as an index of human adrenal cortical activity, although their exact relationship with this activity is not known (1). The urinary 17-ketosteroids may be conversion products of other steroid substances. Administration of any of a wide variety of C19 steroids increases the output of urinary 17-ketosteroids, especially androsterone and etiocholanolone (2, 3). Mason and Kepler (4, 5), and Sayers et al. (6) have suggested that urinary 17-ketosteroids are breakdown products of 21-carbon-atom adrenal cortical steroids. Conn (7) and Polley and Mason (8) reported an increased urinary excretion of 17-ketosteroids following administration of adrenal cortical hormones. Sprague et al. (9) indicate that cortisone may depress urinary 17-ketosteroid excretion due to depression of some of the functions of the cortices, though an increase is reported in patients suffering with Addison's disease. Homburger (10) and Cuyler et al. (11) report no increase in ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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