Circulating tumor cells are associated with poor outcomes in early-stage hepatocellular carcinoma: a prospective study
| Autor: | Sunghyun Yoon, Tae Hun Kim, Jae Eul Shim, Yeonjung Ha, Mi Jung Jun, Han Chu Lee, Young-Ho Cho |
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| Rok vydání: | 2019 |
| Předmět: |
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medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Gastroenterology 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Predictive Value of Tests Internal medicine Biomarkers Tumor medicine Humans Prospective Studies Stage (cooking) Prospective cohort study Neoplasm Staging Proportional Hazards Models Hepatology Proportional hazards model business.industry Liver Neoplasms Hazard ratio Middle Aged Neoplastic Cells Circulating Prognosis medicine.disease Survival Analysis Spain 030220 oncology & carcinogenesis Hepatocellular carcinoma Female 030211 gastroenterology & hepatology Neoplasm Recurrence Local business |
| Zdroj: | Hepatology International. 13:726-735 |
| ISSN: | 1936-0541 1936-0533 |
| Popis: | Previous studies evaluating association between circulating tumor cells (CTCs) and clinical outcomes in hepatocellular carcinoma (HCC) have shown inconsistent results due to suboptimal detection methods and patient heterogeneity. Patients undergoing surgery for early-stage HCC were prospectively enrolled. The CTC numbers were determined using a tapered slit platform, which detects CTCs based on the cell size and morphology. Survival and recurrence were evaluated, and Cox proportional hazards models were used to demonstrate the prognostic significance of CTC. Of 105 patients, 25 had increased CTC numbers after surgery (ΔCTC > 0, defined as positive) and a significantly higher level of recurrence (p = 0.042). A positive ΔCTC was seen to be an independent predictor of recurrence (hazard ratio 2.28), along with hepatitis B virus infection, alanine aminotransferase level, and the presence of satellite nodules (all p |
| Databáze: | OpenAIRE |
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