TIMELY DELIVERY OF BIOLOGICAL THERAPY AFTER CYTOREDUCTIVE NEPHRECTOMY IN CAREFULLY SELECTED PATIENTS WITH METASTATIC RENAL CELL CARCINOMA

Autor:	David A. Swanson, Colin P.N. Dinney, Joel W. Slaton, Julie A. Ellerhorst, David A. Levy
Rok vydání:	1998
Předmět:	Kidney medicine.medical_specialty Performance status business.industry Urology medicine.medical_treatment medicine.disease Nephrectomy Surgery Metastasis medicine.anatomical_structure Renal cell carcinoma Carcinoma medicine Combined Modality Therapy business Kidney disease
Zdroj:	Journal of Urology. 159:1168-1173
ISSN:	1527-3792 0022-5347
Popis:	Purpose: We determine whether cytoreductive surgery delays or precludes the administration of systemic biological therapy in patients with previously untreated metastatic renal cell carcinoma.Materials and Methods: We evaluated 79 patients 22 to 73 years old with untreated renal cell carcinoma for possible cytoreductive surgery before the administration of systemic biological therapy. Based on performance status, overall disease burden and subjective clinical assessment 13 patients were referred for initial systemic biological therapy and 66 underwent cytoreductive surgery as initial treatment. We evaluated patient ability to receive postoperative biological therapy, time to therapy, surgical complications and mortality.Results: Cytoreductive surgery had a minimal impact on the administration of timely systemic biological therapy in these carefully selected patients. Of the 66 patients 54 (82%) received postoperative systemic biological therapy beginning a median of 40 days after nephrectomy. Two ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260eab445684937700e4aa19534a8fe1 https://doi.org/10.1016/s0022-5347(01)63542-0 Zobrazit plný text záznamu