Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules
| Autor: | Young Cheol Na, Won Seok Chang, Jin Woo Chang, Bong Soo Kim, Byeong-Wook Song, Jaewoo Shin, Younghee Seo, Jihyeon Lee, Chanho Kong |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Microscopy Acoustic Biology Mesenchymal Stem Cell Transplantation Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Parenchyma Animals Humans lcsh:QH301-705.5 Cell adhesion molecule Mesenchymal stem cell Cell migration Cell Biology General Medicine Adhesion Rats Transplantation 030104 developmental biology lcsh:Biology (General) Cancer research Stem cell Cell Adhesion Molecules 030217 neurology & neurosurgery Intracellular Developmental Biology |
| Zdroj: | Stem Cell Research, Vol 43, Iss, Pp-(2020) |
| ISSN: | 1876-7753 |
| Popis: | Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells. Keywords: Stem cell transplantation, Mesenchymal stem cells, Cell adhesion molecules, Cell migration, Cytokines, Stem cell-microenvironment interactions |
| Databáze: | OpenAIRE |
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