CCK receptor polymorphisms: an illustration of emerging themes in pharmacogenomics
| Autor: | Kirsten Schaffer, Martin Beinborn, Edward W. McBride, Alan S. Kopin |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
Cck2 receptor Drug Genetics Polymorphism Genetic media_common.quotation_subject Molecular Sequence Data food and beverages Disease Biology Toxicology Bioinformatics Cholecystokinin receptor Species Specificity GTP-Binding Proteins Pharmacogenomics Animals Humans Receptors Cholecystokinin Amino Acid Sequence Receptor Cholecystokinin media_common G protein-coupled receptor |
| Zdroj: | Trends in Pharmacological Sciences. 21:346-353 |
| ISSN: | 0165-6147 |
| DOI: | 10.1016/s0165-6147(00)01526-1 |
| Popis: | Polymorphisms in G-protein-coupled receptors can alter drug affinity and/or activity. In addition, genetic differences in amino acid sequences can induce ligand-independent signaling, which in turn can lead to disease. With growing efforts in the field of pharmacogenomics, it is anticipated that polymorphism-induced alterations in drug and/or receptor function will be a focus of increasing concern during the course of future drug-development efforts. In this review, the spectrum of pharmacological consequences that result from polymorphisms in the cholecystokinin CCK2 receptor will be discussed, thereby illustrating emerging themes in pharmacogenomics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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