| Popis: |
Two new phenolic allopyranosides, named viburluzosides A and B (1, 2), together with eight known phenolic glycosides (3 − 10) were discovered from the stems of Viburnum luzonicum Rolfe under the guidance of LC-MS analyses coupled with bioactivity evaluation. They were purified through various chromatography methods and identified by extensive spectroscopic analyses (1H and 13C NMR, HSQC, HMBC, and HRESIMS) and chemical methods. The in vitro evaluation on α-glucosidase and aldose reductase (AR) inhibitory activities of isolated compounds were conducted. Compounds 1 − 4 and 6 − 9 exhibited α-glucosidase inhibitory activities with IC50 values of 5.35 − 21.34 μM and AR inhibitory activities with IC50 values of 6.21 − 40.06 μM. Moreover, the inhibitory kinetics analyses of compounds 1 and 2 were also performed. |
