Smoking and Helicobacter pylori infection: an individual participant pooled analysis (Stomach Cancer Pooling- StoP Project)
| Autor: | Akihisa Hidaka, Gerson Shigeaki Hamada, Nuno Lunet, Lizbeth López-Carrillo, Mohammadreza Pakseresht, Manolis Kogevinas, Mohammad H. Derakhshan, Nuria Aragonés, David Zaridze, Claudio Pelucchi, Evita Gasenko, Weimin Ye, Marcis Leja, Malaquías López-Cervantes, Samantha Morais, Reza Malekzadeh, Dmitry Maximovitch, Eva Negri, Raúl U. Hernández-Ramírez, Carlo La Vecchia, Shoichiro Tsugane, Amelie Plymoth, Bárbara Peleteiro, Zuo-Feng Zhang, Guo-Pei Yu, Ana Ferro, Farhad Pourfarzi |
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| Přispěvatelé: | A. Ferro, S. Morai, C. Pelucchi, N. Aragoné, M. Kogevina, L. López-Carrillo, R. Malekzadeh, S. Tsugane, G. S. Hamada, A. Hidaka, R. U. Hernández-Ramírez, M. López-Cervante, D. Zaridze, D. Maximovitch, F. Pourfarzi, Z. -F. Zhang, G. -P. Yu, M. Pakseresht, W. Ye, A. Plymoth, M. Leja, E. Gasenko, M. H. Derakhshan, E. Negri, C. La Vecchia, B. Peleteiro, N. Lunet |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research Epidemiology Pooling serology consortium Risk Assessment smoking Helicobacter Infections 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Stomach Neoplasms Prevalence Tobacco Smoking medicine Humans pooled analysi 030212 general & internal medicine Stomach cancer Aged Smokers Helicobacter pylori business.industry Age Factors Public Health Environmental and Occupational Health Case-control study Cancer individual participant data Publication bias Odds ratio Middle Aged medicine.disease Confidence interval Oncology Gastric Mucosa Case-Control Studies 030220 oncology & carcinogenesis Female business Risk assessment Demography |
| Zdroj: | European Journal of Cancer Prevention. 28:390-396 |
| ISSN: | 0959-8278 |
| DOI: | 10.1097/cej.0000000000000471 |
| Popis: | Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using controls from 14 case- control studies participating in the Stomach Cancer Pooling Project. Summary odds ratios and prevalence ratios (PRs), adjusted for age, sex and social class, and the corresponding 95% confidence intervals (CIs) were estimated through random-effects meta-analysis. Heterogeneity was quantified using the I 2 statistic and publication bias with Egger’s test. There was no significant association between smoking (ever vs. never) and H. pylori seropositivity (adjusted odds ratio = 1.08; 95% CI: 0.89 – 1.32; adjusted PR = 1.01; 95% CI: 0.98 – 1.05). The strength of the association did not increase with the intensity or duration of smoking; stratified analyses according to sex, age, region or type of sample did not yield a consistent pattern of variation or statistically significant results, except for participants younger than 55 years and who had been smoking for more than 30 years (adjusted PR = 1.08; 95% CI: 1.02 – 1.15). This is the first collaborative analysis providing pooled estimates for the association between smoking and H. pylori seropositivity, based on detailed and uniform information and adjusting for major covariates. The results do not support an association between smoking and H. pylori infection. |
| Databáze: | OpenAIRE |
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