Captopril Prevents Experimental Autoimmune Myocarditis
| Autor: | Jamie L. Fornek, Lisa M. Godsel, Kegiang Wang, David M. Engman, Agostino Molteni, Juan S. Leon |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Captopril Myocarditis Mice Inbred A Ovalbumin Injections Subcutaneous T cell Immunology Administration Oral Epitopes T-Lymphocyte Cardiomegaly Mice Transgenic Inflammation Myosins Peptidyl-Dipeptidase A Autoantigens Autoimmune Diseases Mice T-Lymphocyte Subsets In vivo Immunity Internal medicine medicine Animals Immunology and Allergy Hypersensitivity Delayed cardiovascular diseases Cells Cultured Autoantibodies Mice Inbred BALB C biology business.industry Autoantibody medicine.disease Up-Regulation Endocrinology medicine.anatomical_structure Enzyme inhibitor biology.protein Cytokines medicine.symptom business Cell Division hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | The Journal of Immunology. 171:346-352 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.171.1.346 |
| Popis: | Captopril, an angiotensin-converting enzyme inhibitor, is widely used in the treatment of a variety of cardiomyopathies, but its effect on autoimmune myocarditis has not been addressed experimentally. We investigated the effect of captopril on myosin-induced experimental autoimmune myocarditis. A/J mice, immunized with syngeneic cardiac myosin, were given 75 mg/L of captopril in their drinking water. Captopril dramatically reduced the incidence and severity of myocarditis, which was accompanied by a reduction in heart weight to body weight ratio and heart weight. Captopril specifically interfered with cell-mediated immunity as myosin delayed-type hypersensitivity (DTH) was reduced, while anti-myosin Ab production was not affected. Captopril-treated, OVA-immunized mice also exhibited a decrease in OVA DTH. In myosin-immunized, untreated mice, injection of captopril directly into the test site also suppressed myosin DTH. Interestingly, captopril did not directly affect Ag-specific T cell responsiveness because neither in vivo nor in vitro captopril treatment affected the proliferation, IFN-γ secretion, or IL-2 secretion by Ag-stimulated cultured splenocytes. These results indicate that captopril ameliorates experimental autoimmune myocarditis and may act, at least in part, by interfering with the recruitment of cells to sites of inflammation and the local inflammatory environment. |
| Databáze: | OpenAIRE |
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