Role of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and Disease
| Autor: | Edward N. Harris, Erika Baker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway Cell signaling Cell Adhesion Molecules Neuronal receptor HARE Motility Review clearance Stabilin-2 Biology ligand Ligands Catalysis Inorganic Chemistry Extracellular matrix hyaluronan lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Protein Domains Neoplasms Animals Humans Disease Amino Acid Sequence Physical and Theoretical Chemistry Receptor Molecular Biology lcsh:QH301-705.5 Spectroscopy Organic Chemistry General Medicine Ligand (biochemistry) Hyaluronan-mediated motility receptor MAPK Computer Science Applications Cell biology Hyaluronan Receptors 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Health 030220 oncology & carcinogenesis signaling Intracellular |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 3504, p 3504 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to ligand binding, cellular signaling, and its role in known physiological disorders such as cancer. |
| Databáze: | OpenAIRE |
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