An investigation of factors limiting aerobic capacity in patients with ankylosing spondylitis
| Autor: | P. Riantawan, R.D. Sturrock, S.W. Banham, R. Carter |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Exercise intolerance Pulmonary function testing Grip strength Internal medicine Respiratory muscle medicine Humans Plethysmograph Spondylitis Ankylosing Muscle Skeletal Lung Aerobic capacity Exercise Tolerance Hand Strength business.industry VO2 max Middle Aged Respiratory Function Tests Case-Control Studies Exercise Test Cardiology Lean body mass Physical therapy Female medicine.symptom Lung Volume Measurements business |
| Zdroj: | Respiratory Medicine. 93(10):700-708 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/s0954-6111(99)90036-7 |
| Popis: | Ankylosing spondylitis (AS) has been shown to produce exercise limitation and breathlessness. The purpose of this study was to investigate factors which may be responsible for limiting aerobic capacity in patients with AS.Twenty patients with no other cardio-respiratory disease performed integrative cardiopulmonary exercise testing (CPET). The results were compared to 20 age and gender matched healthy controls. Variables that might influence exercise tolerance, including pulmonary function tests (body plethysmography), respiratory muscle strength (MIP, MEP) and endurance (Tlim), AS severity assessment including chest expansion (CE), thoracolumber movement (TL), wall tragus distance and peripheral muscle strength assessed by maximum voluntary contraction of the knee extensors (Qds), hand grip strength and lean body mass (LBM), were measured in the patients with AS and used as explanatory variables against the peak V̇O2 achieved during CPET.AS subjects achieved a lower peak V̇O2 than controls (25·2 ± 1·4 vs. 33·1 ± 1·6 ml kg−1min−1, mean ± sem, P=0·001). When compared with controls, ventilatory response (V̇E/V̇CO2) in AS was elevated (P=0·01); however gas exchange indices, transcutaneous blood gases and breathing reserve were similar to controls. AS subjects developed a higher HR/V̇O2 response (P |
| Databáze: | OpenAIRE |
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