Numerical and experimental investigation of mucociliary clearance breakdown in cystic fibrosis
| Autor: | Dominique Anne-Archard, Robin Chatelin, Marc Thiriet, Philippe Poncet, Marlène Murris-Espin |
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| Přispěvatelé: | Université de Lyon, Institut de mécanique des fluides de Toulouse (IMFT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, CHU Toulouse [Toulouse], Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Mathématiques et de leurs Applications [Pau] (LMAP), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), ANR-2010-JCJC-0113-01, ANR-10-JCJC-0113,BioFiReaDy,Films biologiques et Dysfonctionnement Respiratoire(2010), Centre National de la Recherche Scientifique - CNRS (FRANCE), Ecole Nationale d'Ingénieurs de Saint Etienne - ENISE (FRANCE), Ecole Nationale des Travaux Publics de l'Etat - ENTPE (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Université de Paris Diderot - Paris 7 (FRANCE), Université Pierre et Marie Curie, Paris 6 - UPMC (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Ecole Centrale de Lyon (FRANCE), Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE), Université de Pau et des Pays de l'Adour - UPPA (FRANCE), Laboratoire Jacques-Louis Lions - LJLL (Paris, France), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts (FERMAT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Laboratoire Jacques-Louis Lions (LJLL), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Pau et des Pays de l'Adour (UPPA), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Mucociliary clearance Mécanique des fluides Generalized Stokes equations Biomedical Engineering Biophysics 010103 numerical & computational mathematics Pollutant deposition Models Biological Hybrid grid-particle methods 01 natural sciences Cystic fibrosis Computational biology 03 medical and health sciences equations medicine Humans Orthopedics and Sports Medicine [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] 0101 mathematics Lung Viscosity Chemistry Rehabilitation Modeling Partial differential respiratory system medicine.disease Mucus Grid-particle methods 030104 developmental biology medicine.anatomical_structure Rheology Penalization Ciliated epithelium |
| Zdroj: | Journal of Biomechanics Journal of Biomechanics, Elsevier, 2017, 53, pp.56-63. ⟨10.1016/j.jbiomech.2016.12.026⟩ Journal of Biomechanics, Elsevier, 2017, pp.8. ⟨10.1016/j.jbiomech.2016.12.026⟩ |
| ISSN: | 0021-9290 |
| Popis: | International audience; The human tracheobronchial tree surface is covered with mucus. A healthy mucus is an heterogeneous material flowing toward the esophagus and a major defense actor against local pathogen proliferation and pollutant deposition. An alteration of mucus or its environment such as in cystic fibrosis dramatically impacts the mucociliary clearance. In the present study, we investigate the mechanical organization and the physics of such mucus in human lungs by means of a joint experimental and numerical work. In particular, we focus on the influence of the shear-thinning mucus mobilized by a ciliated epithelium for mucociliary clearance. The proposed robust numerical method is able to manage variations of more than 5 orders of magnitude in the shear rate and viscosity. It leads to a cartography that allows to discuss major issues on defective mucociliary clearance in cystic fibrosis. Furthermore, the computational rheological analysis based on measurements shows that cystic fibrosis shear-thinning mucus tends to aggregate in regions of lower clearance. Yet, a rarefaction of periciliary fluid has a greater impact than the mucus shear-thinning effects. |
| Databáze: | OpenAIRE |
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