Incidence, predictors and patterns of care of patients with very severe hypertriglyceridemia in Ontario, Canada: a population-based cohort study

Autor: Amanda J. Berberich, Kristin K. Clemens, Robert A. Hegele, Alexandra Ouédraogo, Salimah Z. Shariff
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Databases
Factual
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Alcohol abuse
030204 cardiovascular system & hematology
Severity of Illness Index
Cohort Studies
0302 clinical medicine
Endocrinology
Risk Factors
Odds Ratio
030212 general & internal medicine
Nutritional diseases. Deficiency diseases
Aged
80 and over
Hypertriglyceridemia
Ontario
education.field_of_study
Incidence (epidemiology)
Incidence
Liver Diseases
Age Factors
Middle Aged
Prognosis
3. Good health
Alcoholism
Hypertension
Female
Cohort study
Adult
medicine.medical_specialty
RC620-627
Adolescent
Population
03 medical and health sciences
Sex Factors
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Obesity
Renal Insufficiency
Chronic
education
Triglycerides
Aged
business.industry
Research
Biochemistry (medical)
Odds ratio
medicine.disease
Confidence interval
Pancreatitis
Secondary hypertriglyceridemia
business
Fibrates
Kidney disease
Zdroj: Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-11 (2021)
Lipids in Health and Disease
Popis: Background The incidence of severe (S-HTG) and very severe hypertriglyceridemia (VS-HTG) among Canadians is unknown. This study aimed to determine the incidence, characteristics, predictors and care patterns for individuals with VS-HTG. Methods Using linked administrative healthcare databases, a population-based cohort study of Ontario adults was conducted to determine incidence of new onset S-HTG (serum triglycerides (TG) > 10–20 mmol/L) and VS-HTG (TG > 20 mmol/L) between 2010 and 2015. Socio-demographic and clinical characteristics of those with VS-HTG were compared to those who had no measured TG value > 3 mmol/L. Univariable and multivariable logistic regression were used to determine predictors for VS-HTG. Healthcare patterns were evaluated for 2 years following first incidence of TG > 20 mmol/L. Results Incidence of S-HTG and VS-HTG in Ontario was 0.16 and 0.027% among 10,766,770 adults ≥18 years and 0.25 and 0.041% among 7,040,865 adults with at least one measured TG, respectively. Predictors of VS-HTG included younger age [odds ratios (OR) 0.64/decade, 95% confidence intervals (CI) 0.62–0.66], male sex (OR 3.83; 95% CI 3.5–4.1), diabetes (OR 5.38; 95% CI 4.93–5.88), hypertension (OR 1.69; 95% CI 1.54–1.86), chronic liver disease (OR 1.71; 95% CI 1.48–1.97), alcohol abuse (OR 2.47; 95% CI 1.90–3.19), obesity (OR 1.49; 95% CI 1.13–1.98), and chronic kidney disease (OR 1.39; 95% CI 1.19–1.63). Conclusion The 5-year incidence of S-HTG and VS-HTG in Canadian adults was 1 in 400 and 1 in 2500, respectively. Males, those with diabetes, obese individuals and those with alcohol abuse are at highest risk for VS-HTG and may benefit from increased surveillance.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje