Incidence, predictors and patterns of care of patients with very severe hypertriglyceridemia in Ontario, Canada: a population-based cohort study
Autor: | Amanda J. Berberich, Kristin K. Clemens, Robert A. Hegele, Alexandra Ouédraogo, Salimah Z. Shariff |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Databases Factual Endocrinology Diabetes and Metabolism Clinical Biochemistry Alcohol abuse 030204 cardiovascular system & hematology Severity of Illness Index Cohort Studies 0302 clinical medicine Endocrinology Risk Factors Odds Ratio 030212 general & internal medicine Nutritional diseases. Deficiency diseases Aged 80 and over Hypertriglyceridemia Ontario education.field_of_study Incidence (epidemiology) Incidence Liver Diseases Age Factors Middle Aged Prognosis 3. Good health Alcoholism Hypertension Female Cohort study Adult medicine.medical_specialty RC620-627 Adolescent Population 03 medical and health sciences Sex Factors Internal medicine Diabetes mellitus medicine Diabetes Mellitus Humans Obesity Renal Insufficiency Chronic education Triglycerides Aged business.industry Research Biochemistry (medical) Odds ratio medicine.disease Confidence interval Pancreatitis Secondary hypertriglyceridemia business Fibrates Kidney disease |
Zdroj: | Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-11 (2021) Lipids in Health and Disease |
Popis: | Background The incidence of severe (S-HTG) and very severe hypertriglyceridemia (VS-HTG) among Canadians is unknown. This study aimed to determine the incidence, characteristics, predictors and care patterns for individuals with VS-HTG. Methods Using linked administrative healthcare databases, a population-based cohort study of Ontario adults was conducted to determine incidence of new onset S-HTG (serum triglycerides (TG) > 10–20 mmol/L) and VS-HTG (TG > 20 mmol/L) between 2010 and 2015. Socio-demographic and clinical characteristics of those with VS-HTG were compared to those who had no measured TG value > 3 mmol/L. Univariable and multivariable logistic regression were used to determine predictors for VS-HTG. Healthcare patterns were evaluated for 2 years following first incidence of TG > 20 mmol/L. Results Incidence of S-HTG and VS-HTG in Ontario was 0.16 and 0.027% among 10,766,770 adults ≥18 years and 0.25 and 0.041% among 7,040,865 adults with at least one measured TG, respectively. Predictors of VS-HTG included younger age [odds ratios (OR) 0.64/decade, 95% confidence intervals (CI) 0.62–0.66], male sex (OR 3.83; 95% CI 3.5–4.1), diabetes (OR 5.38; 95% CI 4.93–5.88), hypertension (OR 1.69; 95% CI 1.54–1.86), chronic liver disease (OR 1.71; 95% CI 1.48–1.97), alcohol abuse (OR 2.47; 95% CI 1.90–3.19), obesity (OR 1.49; 95% CI 1.13–1.98), and chronic kidney disease (OR 1.39; 95% CI 1.19–1.63). Conclusion The 5-year incidence of S-HTG and VS-HTG in Canadian adults was 1 in 400 and 1 in 2500, respectively. Males, those with diabetes, obese individuals and those with alcohol abuse are at highest risk for VS-HTG and may benefit from increased surveillance. |
Databáze: | OpenAIRE |
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