| Autor: |
M M Shmarov, Iu A Smirnov, D N Shcherbinin, E S Sedova, Naroditskiĭ Bs, L. M. Tsybalova, A L Gintsburg, Oleg I. Kiselev, A I Migunov, D Iu Logunov |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Acta Naturae. 4:17-27 |
| ISSN: |
2075-8251 |
| DOI: |
10.32607/20758251-2012-4-4-17-27 |
| Popis: |
This review covers the problems encountered in the construction and production of new recombinant influenza vaccines. New approaches to the development of influenza vaccines are investigated; they include reverse genetics methods, production of virus-like particles, and DNA- and viral vector-based vaccines. Such approaches as the delivery of foreign genes by DNA- and viral vector-based vaccines can preserve the native structure of antigens. Adenoviral vectors are a promising gene-delivery platform for a variety of genetic vaccines. Adenoviruses can efficiently penetrate the human organism through mucosal epithelium, thus providing long-term antigen persistence and induction of the innate immune response. This review provides an overview of the practicability of the production of new recombinant influenza cross-protective vaccines on the basis of adenoviral vectors expressing hemagglutinin genes of different influenza strains. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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