Cerebrospinal fluid biomarkers of β-amyloid metabolism and neuronal damage in epileptic seizures
| Autor: | Niklas Mattsson, Konrad Rejdak, Robert Rejdak, Piotr Ksiazek, Henrik Zetterberg, Pashtun Shahim, Kaj Blennow |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Gene isoform medicine.medical_specialty Pathology Amyloid tau Proteins Status epilepticus Statistics Nonparametric Fatty acid-binding protein Amyloid beta-Protein Precursor Young Adult Cerebrospinal fluid In vivo Internal medicine medicine Amyloid precursor protein Humans Aged Aged 80 and over Amyloid beta-Peptides Epilepsy biology business.industry Electroencephalography Middle Aged Magnetic Resonance Imaging Endocrinology Neurology Brain Injuries Heart-type fatty acid binding protein biology.protein Female Neurology (clinical) medicine.symptom business Biomarkers |
| Zdroj: | European Journal of Neurology. 21:486-491 |
| ISSN: | 1351-5101 |
| DOI: | 10.1111/ene.12336 |
| Popis: | BACKGROUND AND PURPOSE The main objectives of this study were to investigate if epileptic seizures have effects on brain metabolism of β-amyloid (Aβ), as reflected by cerebrospinal fluid (CSF) levels of different isoforms of Aβ peptides and soluble amyloid precursor protein (APP), and neuronal degeneration, as reflected by CSF biomarker signs of acute neuronal injury. METHODS Forty-five patients were included, 21 of whom had single generalized tonic-clonic seizures sGTCS), 11 had repetitive GTCS, 7 had repetitive partial seizures (rPS), 6 had single partial seizure (sPS) and 4 fulfilled the criterion for non-convulsive status epilepticus (nSE). CSF was analyzed for Aβx-38, Aβx-40, Aβx-42, Aβ1-42, soluble APP fragments (sAPP-α/β), total-tau (T-tau) and phosphorylated tau (P-tau), as well as heart-type fatty acid binding protein (H-FABP). RESULTS Patients with seizures had decreased levels of T-tau (P = 0.0016) and P-tau (P = 0.0028) compared with controls, but no differences in H-FABP (P = 0.67). There were no overall differences in Aβ or sAPP peptides between seizure patients and controls. In patients with rPS, the levels of Aβx-38 and Aβx-40 were elevated compared with nSE (P |
| Databáze: | OpenAIRE |
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