Serum immunoglobulin G subclasses and serum immunoglobulin A in acute bronchiolitis in infants
| Autor: | A. B. Solheim, O. J. Mellbye, B. Johansen, A. Danielsen, L. Henrichson, D. Belsnes, P. Fuglerud, K. H. Carlsen |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Immunology Population Immunoglobulin G medicine Immunology and Allergy Humans Respiratory system education education.field_of_study biology Respiratory tract infections business.industry IgA Deficiency Infant Newborn Infant medicine.disease Immunoglobulin A Otitis Bronchiolitis Acute Bronchiolitis Pediatrics Perinatology and Child Health Acute Disease biology.protein Bronchitis Female medicine.symptom business |
| Zdroj: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 4(1) |
| ISSN: | 0905-6157 |
| Popis: | Serum IgG subclasses and Serum IgA were studied in 43 infants with acute bronchiolitis and 20 healthy infants. IgG subclasses were determined by a capture ELISA and IgA was quantified by turbidimetry. IgG1 concentrations were significantly lower in infants with bronchiolitis than in normal infants. The other IgG subclasses and IgA did not differ between the groups. The subgroups of infants with bronchiolitis who had previously suffered from otitis media or bronchitis, had significantly lower IgG2 than the other infants with bronchiolitis. The same was found for infants with bronchiolitis who had suffered from three or more lower respiratory tract infections. In infants who had suffered from upper or lower respiratory infections before the acute bronchiolitis, IgA was significantly higher than in infants without previous respiratory infections. Ten infants with bronchiolitis (23%) had IgG1 deficiency, that is values below the lower reference limit calculated in a population of healthy Norwegian infants. No healthy infants had any IgG1 deficiency. No infant with bronchiolitis had IgG2 or IgG3 deficiency. The low IgG1 values found in infants with acute bronchiolitis, may be one cause for infants to be more susceptible to RS virus infections. |
| Databáze: | OpenAIRE |
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