Prevalence of human T-cell lymphotropic virus type-1 infection among blood donors in mainland China: a systematic review and meta-analysis of the last 20 years
| Autor: | Humin Liu, Xue Chen, Guangxiang Xi, Xuemei Fu, Dingding Zhang, Jinliang Hu, Fang Liu, Yi Feng |
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| Rok vydání: | 2019 |
| Předmět: |
Estimation
Mainland China China Human T-lymphotropic virus 1 business.industry Infection prevalence Distribution (economics) Blood Donors Hematology HTLV-I Infections Confidence interval 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Meta-analysis Environmental health Prevalence Medicine Humans Human T cell lymphotropic virus type 1 business 030215 immunology |
| Zdroj: | Expert review of hematology. 12(8) |
| ISSN: | 1747-4094 |
| Popis: | Background: The southeastern coastal area of China has a high prevalence of HTLV-1 infection among blood donors. However, the estimation of HTLV-1 prevalence on a national and regional level is little known. The aim of this study is to understand and explore the estimation of HTLV-1 infection prevalence among blood donors on a national and regional level in mainland China by using a systematic review and meta-analysis. Study design and methods: All relevant publications of the past two decades (1998-2017), which were reported in both English and Chinese languages, were adopted and systematically assessed. The estimation of prevalence and its 95% confidence interval (CI) at the level of provinces/municipalities and overall were estimated using meta-analysis method. Results: From the 327 studies searched, 60 met the inclusion criteria. These were from 18 provinces and four municipalities and included 1,420,079 blood donors. The overall estimation of the HTLV-1 prevalence in blood donors was 0.169‰, and its 95% CI was 0.121‰-0.240‰. Conclusion: A disproportionate distribution of HTLV-1 infection among blood donors in different provinces/municipalities regarding its prevalence has been reported. This study recommends developing appropriate HTLV-1 screening strategies of blood donors in various regions of China considering regional prevalence, and cost-effectiveness. |
| Databáze: | OpenAIRE |
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