T(14;18)(q32;q21) involving MALT1 and IGH genes in an extranodal diffuse large B-cell lymphoma
| Autor: | Maureen E. Sherer, Fiona E. Craig, Sofia Shekhter-Levin, Steven H. Swerdlow, James R. Cook |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Lymphoma B-Cell Skin Neoplasms Chromosomal translocation Biology Translocation Genetic Pathology and Forensic Medicine immune system diseases hemic and lymphatic diseases medicine Humans neoplasms In Situ Hybridization Fluorescence Aged Chromosome Aberrations Chromosomes Human Pair 14 Genes Immunoglobulin Large-cell lymphoma Cytogenetics Anatomical pathology Lymphoma B-Cell Marginal Zone medicine.disease Marginal zone Neoplasm Proteins Forearm MALT1 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Caspases Cancer research Female Lymphoma Large B-Cell Diffuse Chromosomes Human Pair 18 Diffuse large B-cell lymphoma Mucosa-associated lymphoid tissue |
| Zdroj: | Human Pathology. 34:1212-1215 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/j.humpath.2003.08.007 |
| Popis: | Two translocations involving the MALT1 gene have been described in extranodal marginal zone B-cell lymphomas of MALT type. A t(11;18)(q21;q21) involving API2 and MALT1 occurs in a subset of MALT lymphomas but with only rare exception is absent in diffuse large B-cell lymphomas (DLBCL), even at MALT sites. More recently, a t(14;18)(q32;q21) involving IGH and MALT1 has been described in nongastric extranodal MALT lymphomas. This translocation is indistinguishable from the IGH-BCL2 translocation by using classical cytogenetics. We report the IGH-MALT1 translocation in a cutaneous DLBCL as shown by classical cytogenetics and molecular cytogenetic analysis. This is the first report of an IGH-MALT1 translocation in DLBCL. These findings indicate that MALT1 translocations are not restricted to indolent-appearing lymphomas, provide further evidence that API2-MALT1 and IGH-MALT1 translocations exhibit biologic differences, have implications regarding the pathogenesis of some extranodal DLBCL, and emphasize that a t(14;18)(q32;q21) cannot be assumed to reflect a BCL2 translocation. |
| Databáze: | OpenAIRE |
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