Structural and physico-chemical determinants of the interactions of macrocyclic photosensitizers with cells
| Autor: | Stéphanie Bonneau, Halina Mojzisova, Daniel Brault |
|---|---|
| Přispěvatelé: | Laboratoire de Photonique Quantique et Moléculaire (LPQM), École normale supérieure - Cachan (ENS Cachan)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Laboratoire Jean Perrin (LJP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bonneau, Stéphanie |
| Rok vydání: | 2007 |
| Předmět: |
Macrocyclic Compounds
Chemical Phenomena Photochemistry [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] Biophysics Membrane biology Biology 03 medical and health sciences 0302 clinical medicine Organelle Molecule Animals Humans ComputingMilieux_MISCELLANEOUS 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species Photosensitizing Agents [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] Cell Death Chemistry Physical General Medicine Subcellular localization Cell biology Membrane chemistry 030220 oncology & carcinogenesis Intracellular Subcellular Fractions |
| Zdroj: | European Biophysics Journal European Biophysics Journal, Springer Verlag (Germany), 2007, 36 (8), pp.943-953 European Biophysics Journal, 2007, 36 (8), pp.943-953 |
| ISSN: | 0175-7571 1432-1017 |
| Popis: | New therapies have been developed using reactive oxygen species produced by light-activation of photosensitizers (PS). Since the lifetime of these species is extremely short and their diffusion in space is limited, the photo-induced reactions primarily affect the cell organelles labeled by the PS. In addition to the development of molecules with the best optical and photosensitizing properties, considerable research has been done to understand the physico-chemical parameters governing their subcellular localization. In this review, we examine these parameters to establish the structure/efficacy relationships, which allow specific targeting of PS. We examine the effect of subcellular localization on the cellular response to photosensitization processes. We discuss the determinants of subcellular localization, including the hydrophobic/hydrophilic balance, the specific charge effects and the dynamics of PS’ transfer through membranes. Specific targeting can also be achieved with molecular structures able to recognize cellular or intracellular receptors, and this is also dealt with in this paper. |
| Databáze: | OpenAIRE |
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