Effect of nebivolol on altered skeletal and cardiac muscles induced by dyslipidemia in rats: impact on oxidative and inflammatory machineries
| Autor: | Heba Morsi, Hanan Abdallah, Ghada Farouk Soliman, Nermeen Bastawy, Walaa Ibrahim, Omnia Mohamed Abdel-Maksoud, Mohamed Mansour Khalifa, Laila A. Rashed |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Muscle tissue medicine.medical_specialty Physiology Hyperlipidemias 030209 endocrinology & metabolism medicine.disease_cause High cholesterol Nebivolol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Enos Physiology (medical) Internal medicine medicine Animals Triglycerides biology business.industry Cholesterol Myocardium General Medicine Glutathione medicine.disease biology.organism_classification Rats Oxidative Stress Endocrinology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis business Dyslipidemia Oxidative stress medicine.drug |
| Zdroj: | Archives of Physiology and Biochemistry. 128:463-473 |
| ISSN: | 1744-4160 1381-3455 |
| Popis: | Aim: High cholesterol diet is greatly linked to deleterious health consequences. In this work we tried to explore direct effects of high cholesterol diet on striated (skeletal and cardiac) muscle tissues and the mechanisms by which nebivolol could improve such harmful effects.Methods: The study included 24 healthy adult male albino rats weighing 200-220 grams that were assigned into four groups: control group, control drug group, high cholesterol diet fed groups; one untreated the other was treated with nebivolol.Results: In the cholesterol fed group, we found decreased blood HDL and NO with elevated total cholesterol, triglycerides, myoglobin, CK, LDH, ALP, in addition to elevated muscle tissue levels of HIF-1, NF-kB, MDA, and decreased expression of both eNOS, reduced GSH. Wire hanging test time was shorter in the high cholesterol group than control group rats, which was confirmed histologically by increased striated muscle fibre thickness and cytochrome area %. Nebivolol treatment ameliorated the effects of high cholesterol diet.Conclusion: High cholesterol diet caused myopathic changes in rat striated muscle tissues mostly due to oxidative stress associated with enhanced NF-kB and HIF-1 expression. Nebivolol appears beneficial in the management of hypercholesterolaemia-induced striated muscle injury. |
| Databáze: | OpenAIRE |
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